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高海拔降低 COVID-19 的感染率,但不能降低病死率。

High altitude reduces infection rate of COVID-19 but not case-fatality rate.

机构信息

Department of Computer Science, Universidad Nacional de Ingeniería, Lima, Peru.

University Informatics & Systems Office, Universidad de Lima, Lima, Peru.

出版信息

Respir Physiol Neurobiol. 2020 Oct;281:103494. doi: 10.1016/j.resp.2020.103494. Epub 2020 Jul 15.

Abstract

Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude may reduce COVID-19 infections and case-fatality rates (cases/deaths). We study data from Peru COVID-19 pandemics, which first case was recorded on March 6th, 2020. By June 13, 2020 there were 6498 deaths, and 224,132 SARS-CoV-2 positives. Using data from 185 capitals of provinces with altitudes ranging from 3 to 4342 m, we confirm previous reports that infection with COVID-19 at high altitude is reduced. However, case-fatality rate is not dependent of altitude. We have also presented first evidence that female protection towards death by COVID-19 is reduced as altitude of residence increases.

摘要

新型冠状病毒病(COVID-19)是由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引起的大流行疾病。有研究表明,高海拔地区的生活可能会降低 COVID-19 的感染率和病死率(病例/死亡)。我们研究了秘鲁 COVID-19 大流行的数据,该地区首例病例于 2020 年 3 月 6 日记录。截至 2020 年 6 月 13 日,已有 6498 人死亡,224132 人 SARS-CoV-2 阳性。利用海拔 3 至 4342 米的 185 个省会城市的数据,我们证实了先前的报告,即在高海拔地区感染 COVID-19 的风险降低。然而,病死率并不取决于海拔。我们还首次提出证据表明,随着居住地海拔的升高,女性对 COVID-19 死亡的保护作用降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a936/7361094/3267e7823af8/gr1_lrg.jpg

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