Department of Gastroenterology, Elazig Fethi Sekin Sehir Hastanesi, Elazig, Turkey.
Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Int J Gynaecol Obstet. 2020 Nov;151(2):267-271. doi: 10.1002/ijgo.13309. Epub 2020 Sep 8.
To explore the relationship of lymph node ratio (LNR) and other lymph node parameters with disease-free (DFS) and overall (OS) survival among women with endometrial cancer.
Retrospective analysis of data of women diagnosed with endometrial cancer at Hacettepe University Hospitals, Ankara, Turkey, between 2003 and 2013. Women who had their surgical procedure, pathology review, and follow-up at Hacettepe University Hospitals were included in the study. Receiver operator characteristic (ROC) curve analysis was used to determine the threshold LNR associated with survival.
Overall, 376 women were included in the study. A higher number of excised metastatic lymph nodes was associated with decreased survival. ROC curve analysis determined a threshold LNR of 0.03. Women with LNR higher than 0.03 had decreased DFS (P<0.001) and OS (P<0.001) relative to those with LNR of 0.03 or lower. LNR of 0.1 was found to be a significant cutoff value for DFS (P=0.023) and OS (P=0.036) among women with at least one metastatic lymph node.
LNR may be used as a prognostic tool in endometrial cancer. Future studies will help to define a precise threshold of LNR in order to implement this prognostic factor in daily practice.
探讨淋巴结比率（LNR）和其他淋巴结参数与子宫内膜癌患者无病生存（DFS）和总生存（OS）的关系。
对土耳其安卡拉哈塞特佩大学医院 2003 年至 2013 年间诊断为子宫内膜癌的女性患者数据进行回顾性分析。将在哈塞特佩大学医院进行手术、病理检查和随访的女性纳入研究。采用受试者工作特征（ROC）曲线分析确定与生存相关的 LNR 阈值。
共有 376 名女性纳入研究。切除的转移性淋巴结数量越多，生存情况越差。ROC 曲线分析确定 LNR 的阈值为 0.03。LNR 高于 0.03 的女性 DFS（P<0.001）和 OS（P<0.001）均低于 LNR 为 0.03 或更低的女性。对于至少有一个转移性淋巴结的女性，LNR 为 0.1 是 DFS（P=0.023）和 OS（P=0.036）的显著截断值。
LNR 可作为子宫内膜癌的预后工具。未来的研究将有助于确定 LNR 的精确阈值，以便在日常实践中实施这一预后因素。
