Popik W, Inglot A D, Wilusz T, Polanowski A
Laboratory of Virology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Arch Immunol Ther Exp (Warsz). 1988;36(5):645-53.
The polypeptide proteinase inhibitors (PI) isolated from Cucurbitaceae plants, bovine pancreas, lima bean kale seeds and some other sources were assayed in mouse, rat and human cell cultures for possible mitogenic effects. PI stimulated the proliferation of the spare cultures of Balb/c 3T3 and NRK-49F fibroblasts pretreated with trypsin. PI had no effect on [3H]thymidine incorporation by the monolayer cultures of the mouse or rat cells. Also certain human cell lines were unresponsive to PI. The results suggest that PI have growth factor-like activities which are cell and/or species specific.
从葫芦科植物、牛胰腺、利马豆羽衣甘蓝种子及其他一些来源分离出的多肽蛋白酶抑制剂（PI），在小鼠、大鼠和人类细胞培养物中检测其可能的促有丝分裂作用。PI刺激了用胰蛋白酶预处理过的Balb/c 3T3和NRK - 49F成纤维细胞的备用培养物的增殖。PI对小鼠或大鼠细胞的单层培养物中[3H]胸苷掺入没有影响。而且某些人类细胞系对PI无反应。结果表明PI具有细胞和/或物种特异性的生长因子样活性。
