体力活动与阿尔茨海默病风险：一项双样本孟德尔随机化研究。
Physical activity and risk of Alzheimer disease: A 2-sample mendelian randomization study.
作者信息
Baumeister Sebastian E, Karch André, Bahls Martin, Teumer Alexander, Leitzmann Michael F, Baurecht Hansjörg
机构信息
From Epidemiology (S.E.B.), LMU München, UNIKA-T Augsburg; Independent Research Group, Clinical Epidemiology (S.E.B.), Helmholtz Zentrum München, German Research Center for Environmental Health, Munich; Institute of Epidemiology and Social Medicine (A.K.), University of Münster; Department of Internal Medicine B (M.B.) and Institute for Community Medicine (A.T.), University Medicine Greifswald; DZHK (German Centre for Cardiovascular Research) (M.B., A.T.), Partner Site Greifswald; and Department of Epidemiology and Preventive Medicine (M.F.L., H.B.), University of Regensburg, Germany.
出版信息
Neurology. 2020 Sep 29;95(13):e1897-e1905. doi: 10.1212/WNL.0000000000010013. Epub 2020 Jul 17.
OBJECTIVE
Evidence from observational studies for the effect of physical activity on the risk of Alzheimer disease (AD) is inconclusive. We performed a 2-sample mendelian randomization analysis to examine whether physical activity is protective for AD.
METHODS
Summary data of genome-wide association studies on physical activity and AD were used. The primary study population included 21,982 patients with AD and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNPs) known at < 5 × 10 to be associated with average accelerations and 8 SNPs associated at < 5 × 10 with vigorous physical activity (fraction of accelerations >425 milligravities) served as instrumental variables.
RESULTS
There was no association between genetically predicted average accelerations with the risk of AD (inverse variance weighted odds ratio [OR] per SD increment: 1.03, 95% confidence interval 0.97-1.10, = 0.332). Genetic liability for fraction of accelerations >425 milligravities was unrelated to AD risk.
CONCLUSION
The present study does not support a causal association between physical activity and risk of AD.
目的
观察性研究关于身体活动对阿尔茨海默病（AD）风险影响的证据尚无定论。我们进行了一项双样本孟德尔随机化分析，以检验身体活动是否对AD具有保护作用。
方法
使用了关于身体活动和AD的全基因组关联研究的汇总数据。主要研究人群包括21982例AD患者和41944例认知正常对照。已知与平均加速度相关的8个单核苷酸多态性（SNP）（<5×10 ）以及与剧烈身体活动相关的8个SNP（<5×10 ，加速度分数>425毫重力）用作工具变量。
结果
基因预测的平均加速度与AD风险之间无关联（每标准差增量的逆方差加权比值比[OR]：1.03，95%置信区间0.97 - 1.10， = 0.332）。加速度分数>425毫重力的遗传易感性与AD风险无关。
结论
本研究不支持身体活动与AD风险之间存在因果关联。
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