College of Public Health, University of South Florida, Tampa, FL; The Chiles Center for Healthy Mothers and Babies, College of Public Health, University of South Florida, Tampa, FL.
College of Public Health, University of South Florida, Tampa, FL.
Ann Epidemiol. 2020 Sep;49:20-26. doi: 10.1016/j.annepidem.2020.07.003. Epub 2020 Jul 16.
This study examined the association between sleep duration trajectories from adolescence to young adulthood and the risk of asthma into young adulthood.
Using data from 10,362 participants in the National Longitudinal Study of Adolescent to Adult Health (Add Health) free of asthma at baseline, we constructed trajectories of sleep duration from adolescence (age 13-18 years) to young adulthood (age 24-32 years) and used them to examine the association between sleep duration patterns and the risk of new-onset asthma using a log-binomial regression model after adjusting for potential confounders.
The results revealed that 14.4% of nonasthmatic participants had persistent short sleep duration, whereas 80.0% had adequate sleep duration from adolescence through young adulthood. Consistently short-sleepers had 1.52 times the risk of new-onset asthma by age 32 years (95% CI 1.11, 2.10) compared with consistently adequate sleepers. The association was stronger in those with a family history of asthma (aRR = 2.43, 95% CI 1.15, 5.13) than in those without such history (aRR = 1.43, 95% CI 1.05, 1.95).
We conclude that persistent short sleep duration is associated with an increased risk of new-onset asthma in young adults. This association may be more pronounced among those at high risk of asthma because of family history.
本研究探讨了青少年至成年早期的睡眠时间轨迹与成年早期哮喘发病风险之间的关系。
本研究使用来自国家青少年至成年健康纵向研究（Add Health）的数据，共纳入了 10362 名基线时无哮喘的参与者。我们构建了从青少年期（13-18 岁）到成年早期（24-32 岁）的睡眠时间轨迹，并使用对数二项回归模型调整潜在混杂因素后，来研究睡眠时间模式与新发生哮喘风险之间的关系。
结果显示，14.4%的非哮喘参与者持续存在睡眠时间短，而 80.0%的参与者在青少年期到成年早期期间有足够的睡眠时间。与持续有充足睡眠时间的参与者相比，持续睡眠时间短的参与者在 32 岁时发生新哮喘的风险高 1.52 倍（95%CI 1.11, 2.10）。对于有哮喘家族史的参与者（aRR=2.43，95%CI 1.15, 5.13），这种关联比无家族史的参与者更强（aRR=1.43，95%CI 1.05, 1.95）。
我们得出结论，持续的短睡眠时间与成年早期新发生哮喘的风险增加有关。对于有哮喘家族史的高危人群，这种关联可能更为明显。
