CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui Province, 230026, China.
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui Province, 230026, China..
J Control Release. 2020 Oct 10;326:276-296. doi: 10.1016/j.jconrel.2020.07.010. Epub 2020 Jul 17.
Self-assembled nanostructures are highly promising for controlled delivery of therapeutic and diagnostic agents. However, for conventional drug delivery nanosystems, there exist some intrinsic limitations such as low drug-loading contents, premature and burst release, nanocarrier matrix-associated toxicity and immunogenicity, and poor shelf stability. To address these issues, the covalent integration of active drug molecules into prodrug and polyprodrug amphiphiles and fabrication of self-delivery nanomedicines via controlled molecular self-assembly have emerged as a new paradigm. Moreover, it is crucial to achieve on-demand and selective activation of prodrugs and polyprodrugs in a spatiotemporally controlled manner, thus considerably reducing the occurrence of systemic toxicities. In this context, dynamic variations of reductive/oxidative (redox) milieu across normal and pathological tissues, cells, and cytoplasmic compartments provide accessible biochemical stimuli for triggered release of intact drugs. In this review, we highlight recent progresses on emerging applications of redox-activatable nanostructures self-assembled from prodrug and polyprodrug amphiphiles.
自组装纳米结构在治疗和诊断试剂的控制释放方面具有广阔的应用前景。然而，对于传统的药物输送纳米系统，存在一些内在的局限性，如载药量低、过早和爆发式释放、纳米载体基质相关的毒性和免疫原性、以及较差的货架稳定性。为了解决这些问题，将活性药物分子共价整合到前药和多前药两亲体中，并通过控制分子自组装来制备自传递纳米药物，已经成为一种新的范例。此外，实现前药和多前药的按需和选择性激活，并在时空上进行控制，从而大大降低全身毒性的发生，这一点至关重要。在这种情况下，正常和病理组织、细胞和细胞质隔室中氧化还原（redox）环境的动态变化为触发完整药物释放提供了可利用的生化刺激。在本文中，我们重点介绍了由前药和多前药两亲体自组装的氧化还原激活纳米结构的新兴应用的最新进展。
