Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Germany.
Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Osteoarthritis Cartilage. 2020 Oct;28(10):1351-1361. doi: 10.1016/j.joca.2020.04.020. Epub 2020 Jul 16.
To investigate if cartilage calcification (CC) is a systemic process, the purpose of this study was to determine the prevalence and the amount of meniscal/hyaline CC of the knee joint in the general population by high-resolution imaging (DCR) and to evaluate the association between CC with cartilage degeneration and age.
Cross-sectional DCR-study of 180 knee joints of 90 donors (42 female/48 male, mean age 62.3y). Histological hyaline (OARSI) and meniscal (Krenn) cartilage degeneration was determined of all knees.
CC was observed in 100% of the donors (bilaterally in 98%), hyaline cartilage calcification (HCC) in 92% and meniscal calcification (MC) in 100%. CC was detected in more than three out of six distinct cartilage areas in 84.4% of all knees. The mean amount of CC correlated between both sides of donors, the different analyzed areas of the knee joint and between the various types of cartilage structures. There was more calcification in meniscal than in hyaline cartilage (factor 5.3) and in the medial than the lateral compartment (factor 1.2). HCC/MC were already detectable with only mild cartilage lesions and the amount correlated with histological cartilage degeneration, but not with age.
The present study provides evidence that meniscal and hyaline CC occurs in a pattern that is compatible with CC being a systemically driven process and that meniscal fibrocartilage is more prone to calcification than hyaline cartilage. Furthermore, the age-independent association between the amount of CC and the grade of degeneration in both hyaline and meniscal cartilage, suggests that CC is an obligatory early event in initiating cartilage degeneration.
探讨软骨钙化（CC）是否为全身性过程，本研究旨在通过高分辨率成像（DCR）确定膝关节半月板/透明软骨 CC 的患病率和程度，并评估 CC 与软骨退变和年龄的相关性。
对 90 名供体（42 名女性/48 名男性，平均年龄 62.3 岁）的 180 个膝关节进行横断面 DCR 研究。对所有膝关节进行透明软骨（OARSI）和半月板（Krenn）软骨退变的组织学评估。
在 100%的供体（双侧 98%）中观察到 CC，92%的供体存在透明软骨钙化（HCC），100%的供体存在半月板钙化（MC）。84.4%的膝关节中 CC 出现在六个不同软骨区域中的三个以上。供体两侧、膝关节不同分析区域以及各种类型软骨结构之间的 CC 量存在相关性。半月板软骨的钙化程度（因素 5.3）明显高于透明软骨，内侧关节腔的钙化程度（因素 1.2）也明显高于外侧关节腔。HCC/MC 仅在轻度软骨病变时即可检测到，且其程度与组织学软骨退变相关，但与年龄无关。
本研究提供了证据表明，半月板和透明软骨 CC 的发生模式与 CC 作为一种全身性驱动过程是一致的，且半月板纤维软骨比透明软骨更容易发生钙化。此外，CC 程度与透明软骨和半月板软骨退变程度之间与年龄无关的相关性提示，CC 是引发软骨退变的一个早期必需事件。
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