踝关节软骨钙化与普通人群的骨关节炎相关。
Cartilage calcification of the ankle joint is associated with osteoarthritis in the general population.
作者信息
Hubert Jan, Weiser Lukas, Hischke Sandra, Uhlig Annemarie, Rolvien Tim, Schmidt Tobias, Butscheidt Sebastian Karl, Püschel Klaus, Lehmann Wolfgang, Beil Frank Timo, Hawellek Thelonius
机构信息
Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
出版信息
BMC Musculoskelet Disord. 2018 May 24;19(1):169. doi: 10.1186/s12891-018-2094-7.
BACKGROUND
Cartilage calcification (CC) is associated with osteoarthritis (OA) in weight-bearing joints, such as the hip and the knee. However, little is known about the impact of CC and degeneration on other weight-bearing joints, especially as it relates to the occurrence of OA in the ankles. The goal of this study is to analyse the prevalence of ankle joint cartilage calcification (AJ CC) and to determine its correlation with factors such as histological OA grade, age and BMI in the general population.
METHODS
CC of the distal tibia and talus in 160 ankle joints obtained from 80 donors (mean age 62.4 years, 34 females, 46 males) was qualitatively and quantitatively analysed using high-resolution digital contact radiography (DCR). Correlations with factors, such as the joint's histological OA grade (OARSI score), donor's age and BMI, were investigated.
RESULTS
The prevalence of AJ CC was 51.3% (95% CI [0.40, 0.63]), independent of gender (p = 0.18) and/or the joint's side (p = 0.82). CC of the distal tibia was detected in 35.0% (28/80) (95% CI [0.25, 0.47]) and talar CC in 47.5% (38/80) (95% CI [0.36, 0.59]) of all cases. Significant correlations were noted between the mean amount of tibial and talar CC (r = 0.59, p = 0.002), as well as between the mean amount of CC observed in one ankle joint with that of the contralateral side (r = 0.52, p = 0.02). Furthermore, although the amount of AJ CC observed in the distal tibia and talus correlated with the histological OA-grade of the joint (r = 0.70, p < 0.001 and r = 0.72, p < 0.001, respectively), no such correlation was seen in the general population with relation to age (p = 0.32 and p = 0.49) or BMI (p = 0.51 and p = 0.87).
CONCLUSION
The prevalence of AJ CC in the general population is much higher than expected. The relationship between the amount of AJ CC and OA, independent of the donors' age and BMI, indicates that CC may play a causative role in the development of OA in ankles.
背景
软骨钙化（CC）与负重关节（如髋和膝）的骨关节炎（OA）相关。然而，关于CC和退变对其他负重关节的影响知之甚少，尤其是与踝关节OA发生的关系。本研究的目的是分析踝关节软骨钙化（AJ CC）的患病率，并确定其与一般人群中组织学OA分级、年龄和体重指数等因素的相关性。
方法
使用高分辨率数字接触放射摄影（DCR）对从80名捐赠者（平均年龄62.4岁，女性34名，男性46名）获取的160个踝关节的胫骨远端和距骨的CC进行定性和定量分析。研究其与关节的组织学OA分级（OARSI评分）、捐赠者年龄和体重指数等因素的相关性。
结果
AJ CC的患病率为51.3%（95%CI[0.40,0.63]），与性别（p = 0.18）和/或关节侧别（p = 0.82）无关。在所有病例中，35.0%（28/80）（95%CI[0.25,0.47]）的病例检测到胫骨远端CC，47.5%（38/80）（95%CI[0.36,0.59]）的病例检测到距骨CC。胫骨和距骨CC的平均量之间存在显著相关性（r = 0.59，p = 0.002），以及在一个踝关节中观察到的CC平均量与对侧之间也存在显著相关性（r = 0.52，p = 0.02）。此外，虽然在胫骨远端和距骨中观察到的AJ CC量与关节的组织学OA分级相关（分别为r = 0.70，p < 0.001和r = 0.72，p < 0.001），但在一般人群中与年龄（p = 0.32和p = 0.49）或体重指数（p = 0.51和p = 0.87）无此相关性。
结论
一般人群中AJ CC的患病率远高于预期。AJ CC量与OA之间的关系，独立于捐赠者的年龄和体重指数，表明CC可能在踝关节OA的发展中起致病作用。
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