美国胃腺癌的年龄相关趋势。
Age-Based Trends of Gastric Adenocarcinoma in the United States.
作者信息
Trumbull Denslow, Lemini Riccardo, F Elli Enrique, P Bagaria Sanjay, Attwood Kristopher, Gabriel Emmanuel
机构信息
University of Florida, College of Medicine, Gainesville, FL, USA.
Department of Surgery, Mayo Clinic, Jacksonville, FL, USA.
出版信息
Am Surg. 2020 May;86(5):407-414. doi: 10.1177/0003134820918250.
BACKGROUND
Recent studies have shown an increase in the incidence of gastric cancer (GC) among young adults in Asia and Latin America. However, it is unknown if a similar trend is happening in the United States.
METHODS
A retrospective review of the National Cancer Database was conducted to identify patients diagnosed with gastric adenocarcinoma between the years of 2004 and 2013.
RESULTS
A total of 93 734 patients were included. The two age groups below 40 did not see a change in GC incidence; however, age groups above 40 had increasing incidence. Patients aged 18 to 25 had the largest proportion of stage 4 disease and a poor survival (median 11.5 months), compared to older patients.
CONCLUSION
Despite the increasing trend of GC among individuals, the incidence of GC among young adults is not increasing. However, this subpopulation presents at more advanced stages (clinical stage 4) and thus has worse survival.
背景
最近的研究表明，亚洲和拉丁美洲的年轻成年人中胃癌（GC）发病率有所上升。然而，美国是否也出现类似趋势尚不清楚。
方法
对国家癌症数据库进行回顾性研究，以确定2004年至2013年间被诊断为胃腺癌的患者。
结果
共纳入93734例患者。40岁以下的两个年龄组的胃癌发病率没有变化；然而，40岁以上的年龄组发病率呈上升趋势。与老年患者相比，18至25岁的患者IV期疾病比例最高，生存率较差（中位生存期11.5个月）。
结论
尽管总体人群中胃癌发病率呈上升趋势，但年轻成年人中的胃癌发病率并未增加。然而，这一亚组患者就诊时疾病分期更晚（临床IV期），因此生存率更差。
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