Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Chin Med Sci J. 2020 Jun 30;35(2):186-190. doi: 10.24920/003653.
Acute lymphoblastic leukemia (ALL) is a common pediatric cancer. The second malignant neoplasms (SMNs) in long-term survivors of pediatric ALL are relatively rare. Herein we report a 10-year-old girl who was diagnosed as primitive neuroectodermal tumor (PNET) 5 years after the initial diagnosis of ALL with radiotherapy-free treatment. PNET is an exceedingly rare neoplasm in SMNs of survivors of childhood ALL. It is predisposed to be misdiagnosed and the pathogenesis is unclear. The outcome is poor. Long-term follow-up is necessary for the survival children of ALL.
急性淋巴细胞白血病（ALL）是一种常见的儿科癌症。儿科 ALL 长期幸存者中的第二恶性肿瘤（SMNs）相对较少。在此，我们报告了一例 10 岁女孩，她在初诊 ALL 后 5 年接受了无放疗治疗，被诊断为原始神经外胚层肿瘤（PNET）。PNET 是儿童 ALL 幸存者 SMNs 中极为罕见的肿瘤。它容易被误诊，发病机制尚不清楚。预后较差。ALL 幸存者的儿童需要进行长期随访。
