Ammendola D, De Sarro A, De Sarro G B, Germanà G, Naccari F, Rotiroti D
Institute of Pharmacology, Faculty of Medicine and Veterinary Medicine, University of Messina, Italy.
Exp Biol. 1988;48(1):13-7.
The anticonvulsant activity of avermectin B (AVM) was studied after systemic administration in DBA/2 mice (seizures induced by sound) and rats (seizures induced by pentylenetetrazol, cephazolin and maximal electroshock test). Protection against sound-induced seizures was given after intraperitoneal administration of AVM (30 and 50 mg/kg). Cephazolin-induced seizures in rats were attenuated by intraperitoneal administration of AVM (10 and 20 mg/kg). AVM increased the antipentylenetetrazol activity of diazepam. No significant protection against the tonic component in the electroshock test was observed. Behavioural effects of AVM included signs of sedation in both mice and rats. In all, these results indicate that, besides its specific anthelmintic effects, AVM possesses anticonvulsant properties, the mechanism(s) of which still remain to be elucidated.
在DBA/2小鼠（声音诱导癫痫发作）和大鼠（戊四氮、头孢唑林诱导癫痫发作及最大电休克试验）中，研究了阿维菌素B（AVM）全身给药后的抗惊厥活性。腹腔注射AVM（30和50mg/kg）可预防声音诱导的癫痫发作。腹腔注射AVM（10和20mg/kg）可减轻大鼠头孢唑林诱导的癫痫发作。AVM增强了地西泮对戊四氮的抗惊厥活性。在电休克试验中未观察到对强直成分的显著保护作用。AVM的行为效应包括小鼠和大鼠的镇静迹象。总之，这些结果表明，除了其特定的驱虫作用外，AVM还具有抗惊厥特性，其作用机制仍有待阐明。
