Servicio de anestesiología y cirugía, Centro de Rehabilitación y Hospital Equino Kawell, Solís, Provincia de Buenos Aires, Argentina.
Instituto de Investigación, Escuela de Veterinaria, Universidad del Salvador, Pilar, Buenos, Aires, Argentina.
J Equine Vet Sci. 2020 Aug;91:103111. doi: 10.1016/j.jevs.2020.103111. Epub 2020 May 8.
Xylazine and remifentanil in constant rate infusion (CRI) could be used for sedation in horses without adverse effects. The objective was to evaluate behavioral and cardiopulmonary effects of an intravenous (IV) infusion of xylazine and remifentanil for sedation in horses. Xylazine (0.8 mg/kg IV) followed after 3 minutes by a CRI of xylazine and remifentanil (0.65 mg/kg/h and 6 μg/kg/h, respectively) was administered in 10 healthy horses for 60 minutes. Sedation, ataxia, and cardiopulmonary, hematological, and blood gases variables were evaluated. Heart rate decreased significantly during the first 25 minutes after CRI of xylazine and remifentanil, whereas the respiratory rate showed a significant decrease at 20 minutes and remained significantly low until the endpoint. There were no statistically significant fluctuations in blood arterial pressure, blood pH, partial pressure of arterial carbon dioxide, lactate, creatinine, calcium, chlorine, and sodium, compared with baseline values. Blood partial pressure of arterial oxygen and bicarbonate values were significantly higher compared with baseline values, whereas potassium decreased. Sedation and ataxia developed immediately after the administration of xylazine in all horses. All horses recovered successfully within 10 minutes after interruption of the CRI of xylazine and remifentanil, with no ataxia. No adverse effects were observed. The use of a combination of xylazine and remifentanil as sedation protocol has no adverse effects at the described dosage.
盐酸右美托咪定和瑞芬太尼持续输注（CRI）可用于镇静马匹，无不良反应。本研究旨在评估静脉注射（IV）给予右美托咪定和瑞芬太尼用于马匹镇静的行为和心肺效应。10 匹健康马静脉注射右美托咪定（0.8mg/kg）3 分钟后，开始 CRI 输注右美托咪定和瑞芬太尼（分别为 0.65mg/kg/h 和 6μg/kg/h），持续 60 分钟。评估镇静、共济失调和心肺、血液学及血气变量。在右美托咪定和瑞芬太尼 CRI 后的前 25 分钟，心率显著下降，而呼吸频率在 20 分钟时显著下降，并一直保持在低水平直至终点。与基线值相比，动脉血压、血 pH 值、动脉二氧化碳分压、乳酸、肌酐、钙、氯和钠无统计学显著波动。与基线值相比，动脉血氧分压和碳酸氢盐值显著升高，而钾降低。所有马匹在给予右美托咪定后立即出现镇静和共济失调。所有马匹在停止右美托咪定和瑞芬太尼 CRI 后 10 分钟内均成功恢复，无共济失调。未观察到不良反应。在描述的剂量下，使用右美托咪定和瑞芬太尼组合作为镇静方案没有不良反应。
