Creighton J A, Chevins P F
Department of Anatomy, School of Medicine, University of Missouri, Columbia 65212.
Exp Biol. 1988;48(1):57-62.
Stress by crowding and disturbance during the final third of pregnancy in mice advanced the onset of the diurnal plasma corticosterone rhythm in the male offspring from day 25 to day 18. Treated pups showed this altered development whether fostered to treated or to control dams, but it was not apparent in control pups raised by treated dams. Graded adrenocortical responses to increasingly stressful stimuli were not affected by stress during gestation.
在小鼠怀孕最后三分之一阶段，拥挤和干扰造成的应激使雄性后代的昼夜血浆皮质酮节律的开始时间从第25天提前到了第18天。无论将受处理的幼崽寄养给受处理的母鼠还是对照母鼠，它们都表现出这种发育变化，但由受处理的母鼠抚养的对照幼崽却未出现这种情况。孕期应激并未影响肾上腺皮质对压力逐渐增加的刺激的分级反应。
