Schueth Elizabeth A, Martinez Daniel C, Kulwin Charles G, Bonnin Jose M, Payner Troy D, Ting Jonathan Y
Indiana University School of Medicine, 1120 W. Michigan Street, Suite 200, Indianapolis, IN 46202, USA.
Department of Otolaryngology - Head and Neck Surgery, Indiana University School of Medicine, 1130 W. Michigan Street, Fesler Hall, Suite 400, Indianapolis, IN 46202, USA.
Case Rep Otolaryngol. 2020 Jun 26;2020:2580160. doi: 10.1155/2020/2580160. eCollection 2020.
We describe a case of an 81-year-old male presenting with bitemporal visual field defects and blurry vision in the right eye. The patient was found to have a recurrent primary paraganglioma in the sellar and suprasellar region requiring a repeat transsphenoidal endoscopic resection. Immunohistochemical examination confirmed paraganglioma with the classic zellballen appearance which stained positive for chromogranin, synaptophysin, and S-100 in the periphery. Paragangliomas (PGLs) in the sella turcica are a rare entity; only 19 cases have ever been reported in the literature. PGLs in the sellar region are often misdiagnosed or diagnosed in a delayed fashion. Earlier diagnosis of this locally aggressive tumor and meticulous debulking can prevent morbidity secondary to the tumor's compressive effects. This report highlights the effectiveness of surgical interventions in treatment of paragangliomas. More research is still needed to determine the need for adjuvant therapies such as radiation.
我们描述了一例81岁男性患者，其表现为双颞侧视野缺损及右眼视力模糊。该患者被发现蝶鞍和鞍上区域存在复发性原发性副神经节瘤，需要再次行经蝶窦内镜切除术。免疫组化检查证实为具有典型巢状结构的副神经节瘤，其周边嗜铬粒蛋白、突触素和S-100染色呈阳性。蝶鞍区副神经节瘤是一种罕见的疾病；文献中仅报道过19例。蝶鞍区副神经节瘤常被误诊或诊断延迟。早期诊断这种具有局部侵袭性的肿瘤并进行细致的肿瘤切除可预防肿瘤压迫效应导致的并发症。本报告强调了手术干预在治疗副神经节瘤方面的有效性。仍需要更多研究来确定是否需要辅助治疗，如放疗。
