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评估 Xpert MTB/RIF 检测在诊断淋巴结核中的应用。

Evaluation of Xpert MTB/RIF for the Diagnosis of Lymphatic Tuberculosis.

机构信息

Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou 511436, China.

Nanshan School, Guangzhou Medical University, Guangzhou 511436, China.

出版信息

Biomed Res Int. 2020 Jun 28;2020:1968487. doi: 10.1155/2020/1968487. eCollection 2020.

DOI:10.1155/2020/1968487
PMID:32685449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7338981/
Abstract

BACKGROUND

The World Health Organization approved the use of Xpert MTB/RIF for the detection of DNA, which has significantly improved the diagnosis of tuberculosis. In this study, our main objective was to evaluate the diagnostic efficacy of Xpert MTB/RIF for lymphoid tuberculosis to determine whether Xpert MTB/RIF could be used as a routine detection method.

MATERIALS AND METHODS

We searched four databases for the relevant literature published from May 2007 to December 2019. The quality of the literature was evaluated with reference to the evaluation criteria. Data that were extracted from the literature on Xpert MTB/RIF diagnosis of lymphatic tuberculosis were used to plot the summary receiver operating characteristic (SROC) curve, after which the software was used to combine and analyze the accuracy of these data.

RESULTS

A total of 27 studies were included. The sensitivity of Xpert MTB/RIF for detecting lymphatic tuberculosis was 0.79 (95% CI (0.77, 0.81)), the specificity was 0.88 (95% CI (0.87, 0.90)), and the positive likelihood ratio (PLR) was 7.21 (95% CI (4.93, 10.55)). In addition, the negative likelihood ratio (NLR) was 0.25 (95% CI (0.19, 0.32)) and the diagnostic odds ratio (DOR) was 40.23 (95% CI (24.53, 65.98)). At the same time, we used the extracted data to make the SROC curve, obtaining the following parameters: area under the curve (AUC) = 0.9144, = 0.8470 (SE = 0.0163).

CONCLUSION

Xpert MTB/RIF has high accuracy in detecting lymphatic tuberculosis, and it can be used to quickly and easily diagnose lymphatic tuberculosis at an early stage as a general method.

摘要

背景

世界卫生组织批准使用 Xpert MTB/RIF 检测 DNA，这极大地提高了结核病的诊断水平。本研究旨在评估 Xpert MTB/RIF 对淋巴结结核的诊断效能，判断其是否可作为常规检测方法。

材料和方法

检索 2007 年 5 月至 2019 年 12 月期间发表的相关文献，参考评价标准对文献质量进行评价。提取 Xpert MTB/RIF 对淋巴结结核诊断效能的文献数据绘制汇总受试者工作特征（SROC）曲线，采用软件对这些数据的准确性进行综合分析。

结果

共纳入 27 项研究。Xpert MTB/RIF 检测淋巴结结核的敏感度为 0.79（95%CI 0.770.81），特异度为 0.88（95%CI 0.870.90），阳性似然比为 7.21（95%CI 4.9310.55），阴性似然比为 0.25（95%CI 0.190.32），诊断比值比为 40.23（95%CI 24.53~65.98）。提取数据绘制 SROC 曲线，曲线下面积为 0.9144，约登指数为 0.8470（SE=0.0163）。

结论

Xpert MTB/RIF 对淋巴结结核具有较高的诊断效能，可作为一种快速、简便的常规检测方法，用于早期诊断淋巴结结核。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/427f9176b5bc/BMRI2020-1968487.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/9e45dbd2beaf/BMRI2020-1968487.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/32d86fc3d2f1/BMRI2020-1968487.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/1cfec14d9b2a/BMRI2020-1968487.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/f404ac1b2938/BMRI2020-1968487.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/0fc34e6f8fd9/BMRI2020-1968487.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/111fddad4152/BMRI2020-1968487.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/427f9176b5bc/BMRI2020-1968487.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/9e45dbd2beaf/BMRI2020-1968487.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/32d86fc3d2f1/BMRI2020-1968487.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/1cfec14d9b2a/BMRI2020-1968487.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/f404ac1b2938/BMRI2020-1968487.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/0fc34e6f8fd9/BMRI2020-1968487.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/111fddad4152/BMRI2020-1968487.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/370f/7338981/427f9176b5bc/BMRI2020-1968487.007.jpg

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