Famulari Gabriel, Linares Rosales Haydee M, Dupere Justine, Medich David C, Beaulieu Luc, Enger Shirin A
Medical Physics Unit, McGill University, Montreal, QC, H4A 3J1, Canada.
Département de physique, de génie physique et d'optique et Centre de recherche sur le cancer, Université Laval, QC, G1R 2J6, Canada.
Med Phys. 2020 Sep;47(9):4563-4573. doi: 10.1002/mp.14336. Epub 2020 Jul 19.
A prototype Yb source was developed in combination with a dynamic rotating platinum shield system (AIM-Brachy) to deliver intensity modulated brachytherapy (IMBT). The purpose of this study was to evaluate the dosimetric characteristics of the bare/shielded Yb source using Monte Carlo (MC) simulations and perform an independent dose verification using a dosimetry platform based on a multipoint plastic scintillator detector (mPSD).
The TG-43U1 dosimetric parameters were calculated for the source model using RapidBrachyMCTPS. Real-time dose rate measurements were performed in a water tank for both the bare/shielded source using a custom remote afterloader. For each dwell position, the dose rate was independently measured by the three scintillators (BCF-10, BCF-12, and BCF-60). For the bare source, dose rate was measured at distances up to 3 cm away from the source over a range of 7 cm along the catheter. For the shielded source, measurements were performed with the mPSD placed at 1 cm from the source at four different azimuthal angles ( , 9 , 18 , and 27 ).
The dosimetric parameters were tabulated for the source model. For the bare source, differences between measured and calculated along-away dose rates were generally below 5-10%. Along the transverse axis, deviations were, on average (range), 3.3% (0.6-6.2%) for BCF-10, 1.7% (0.9-2.9%) for BCF-12, and 2.2% (0.3-4.4%) for BCF-60. The maximum dose rate reduction due to shielding at a radial distance of 1 cm was 88.8 ± 1.2%, compared to 83.5 ± 0.5% as calculated by MC.
The dose distribution for the bare/shielded Yb source was independently verified using mPSD with good agreement in regions close to the source. The Yb source coupled with the partial-shielding system is an effective technique to deliver IMBT.
开发了一种与动态旋转铂屏蔽系统(AIM - Brachy)相结合的原型镱源,用于实施调强近距离放射治疗(IMBT)。本研究的目的是使用蒙特卡罗(MC)模拟评估裸/屏蔽镱源的剂量学特征,并使用基于多点塑料闪烁探测器(mPSD)的剂量学平台进行独立剂量验证。
使用RapidBrachyMCTPS计算源模型的TG - 43U1剂量学参数。使用定制的遥控后装设备在水箱中对裸/屏蔽源进行实时剂量率测量。对于每个驻留位置,由三个闪烁体(BCF - 10、BCF - 12和BCF - 60)独立测量剂量率。对于裸源,在沿导管7 cm的范围内,在距源最远3 cm处测量剂量率。对于屏蔽源,将mPSD放置在距源1 cm处,在四个不同方位角(0°、90°、180°和270°)进行测量。
列出了源模型的剂量学参数。对于裸源,测量的和计算的沿远离方向剂量率之间的差异通常低于5 - 10%。在横轴上,BCF - 10的偏差平均(范围)为3.3%(0.6 - 6.2%),BCF - 12为1.7%(0.9 - 2.9%),BCF - 60为2.2%(0.3 - 4.4%)。在径向距离1 cm处,屏蔽导致的最大剂量率降低为88.8 ± 1.2%,而MC计算值为83.5 ± 0.5%。
使用mPSD独立验证了裸/屏蔽镱源的剂量分布,在靠近源的区域具有良好的一致性。镱源与部分屏蔽系统相结合是实施IMBT的有效技术。