The College of Pharmacotherapy of Thailand, The Pharmacy Council, Nonthaburi, Thailand.
Department of Pharmacy Practice and Pharmaceutical Care, Faculty of Pharmaceutical Sciences, Burapha University, Chon Buri, Thailand.
J Clin Pharm Ther. 2020 Dec;45(6):1486-1488. doi: 10.1111/jcpt.13221. Epub 2020 Jul 19.
Triazole antifungal-associated skin rash is rare. Data on cross-reaction triazole antifungals remain inconclusive and poorly defined. We report successful voriconazole challenge in a patient allergic to posaconazole.
A 38-year-old female diagnosed with acute myeloid leukaemia and receiving chemotherapy treatment in our institution developed a maculopapular rash after receiving oral posaconazole for invasive fungal infection prophylaxis. Other potential causes that may have attributed to this response, such as other drugs that the patient was taking and infections, were excluded. Voriconazole, another triazole antifungal, was successfully substituted for posaconazole.
This is the first case report of a patient, with a history of posaconazole allergy, successfully challenged with voriconazole.
三唑类抗真菌药相关的皮疹罕见。关于交叉反应性三唑类抗真菌药的数据仍不确定且定义不明确。我们报告了一例对泊沙康唑过敏的患者成功接受伏立康唑挑战的情况。
一位 38 岁的女性因患有急性髓系白血病，在我院接受化疗治疗，在接受泊沙康唑口服预防侵袭性真菌感染后出现斑丘疹。已排除其他可能导致这种反应的潜在原因，如患者正在服用的其他药物和感染。成功用另一种三唑类抗真菌药伏立康唑替代了泊沙康唑。
这是首例报道的泊沙康唑过敏史患者成功接受伏立康唑挑战的病例。
