From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
Division of Internal Medicine, Department of Cardiology, NYU Winthrop Hospital, Mineola (J.G.).
Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2045-2053. doi: 10.1161/ATVBAHA.120.314513. Epub 2020 Jul 20.
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.
2019 年冠状病毒病(COVID-19)大流行给转化研究者带来了前所未有的挑战和机遇,使他们能够迅速开发安全有效的治疗干预措施。患有合并糖尿病、肥胖症和心脏病的 COVID-19 患者发生严重疾病的风险更高,这可能归因于与 COVID-19 和心血管代谢疾病相关的血管炎症途径的协同激活。这种机制联系为心血管代谢疾病治疗药物的转化研究提供了一个科学框架,这些药物可作为新型治疗干预措施,减轻炎症并改善 COVID-19 患者的结局。