Department of Radiology Mayo Clinic Rochester MN.
Department of Neurosurgery Mayo Clinic Rochester MN.
J Am Heart Assoc. 2020 Jul 7;9(13):e016793. doi: 10.1161/JAHA.120.016793. Epub 2020 May 12.
The severe acute respiratory syndrome coronavirus 2 pandemic of 2019 to 2020 has resulted in multiple hospitalizations, deaths, and economic hardships worldwide. Although respiratory involvement in patients with coronavirus disease 2019 (COVID-19) is well known, the potential cardiovascular and cerebrovascular manifestations are less understood. We performed a PubMed and Google Scholar search and reviewed relevant literature on COVID-19 and cardiovascular system involvement. Severe acute respiratory syndrome coronavirus 2 possesses high affinity for angiotensin-converting enzyme 2 receptor, which is highly concentrated in the lungs and cardiovascular tissue, thereby provoking concern for cardiovascular involvement in COVID-19 cases. Preexisting cardiovascular and cerebrovascular disease has been shown in previous reports to be a risk factor for severe infection. On the basis of our review of published studies, COVID-19 patients may be more likely to experience acute cardiac injury, arrhythmia, coagulation defects, and acute stroke and are likely to have poorer outcomes as a result. As the COVID-19 pandemic continues, more data about potential cardiovascular and cerebrovascular manifestations of the disease are required.
2019 年至 2020 年期间爆发的严重急性呼吸综合征冠状病毒 2 型疫情导致全球范围内出现了大量住院、死亡和经济困难。尽管人们熟知新型冠状病毒病（COVID-19）患者的呼吸道受累情况，但对其潜在的心血管和脑血管表现了解较少。我们进行了 PubMed 和 Google Scholar 检索，并对 COVID-19 和心血管系统受累的相关文献进行了综述。严重急性呼吸综合征冠状病毒 2 对血管紧张素转换酶 2 受体具有高亲和力，而这种受体在肺部和心血管组织中高度集中，因此引发了对 COVID-19 病例中心血管受累的关注。既往报告显示，先前存在的心血管和脑血管疾病是严重感染的危险因素。根据我们对已发表研究的综述，COVID-19 患者更有可能出现急性心脏损伤、心律失常、凝血缺陷和急性中风，并且可能因此导致预后较差。随着 COVID-19 大流行的持续，需要更多关于该病潜在心血管和脑血管表现的相关数据。
