Shakes Pieta, Cashin Andrew, Hurley John
J Obstet Gynecol Neonatal Nurs. 2020 Sep;49(5):423-436. doi: 10.1016/j.jogn.2020.06.003. Epub 2020 Jul 17.
To map and summarize the literature related to the prenatal diagnosis of agenesis of the corpus callosum (ACC) to inform nursing practice.
We searched MEDLINE, CINAHL, PyscINFO, and Academic Search Complete with the use of strings of curated terms to cover the broad ACC nomenclature. Documents were published in English between 2009 and June 1, 2020. We also hand searched the reference lists of included documents.
We screened 582 abstracts and retrieved the full texts of primary research articles, reviews, discussion papers, and peer-reviewed book chapters if the abstracts specifically mentioned ACC and the prenatal period. We excluded case reports, conference and poster abstracts, papers on broader anomalies, and animal studies. We reviewed 84 full-text documents and identified 61 for inclusion.
We charted the data through an iterative process under headings for location, article type, study design, participant age, ACC type, recruitment, method, tools/assessments, results, key recommendations, gestational age at diagnosis, termination of pregnancy rate, the definition of isolated ACC, and our notes of critique of the document.
We constructed a narrative synthesis from thematically arranged data. In the included documents, ACC was diagnosed between 17 and 38 weeks gestation and was frequently described as heterogeneous because of different causes, presentations, and outcomes. Whether the ACC was isolated as the only anomaly or present with other anomalies was considered the key factor for prenatal counseling. However, the definition of isolated ACC was inconsistent.
The inconsistent nomenclature and definitions of an isolated presentation of ACC increase the ambiguity in the prenatal diagnosis and must be considered when the outcome and diagnostic efficacy studies are interpreted. There is an absence of research on parents' experiences of prenatal diagnoses of ACC to inform holistic nursing interventions and the provision of psychosocial support.
梳理并总结与胼胝体发育不全（ACC）产前诊断相关的文献，为护理实践提供参考。
我们使用经过整理的术语串搜索了MEDLINE、CINAHL、PyscINFO和Academic Search Complete数据库，以涵盖广泛的ACC术语。文献发表时间为2009年至2020年6月1日，语言为英文。我们还手动检索了纳入文献的参考文献列表。
我们筛选了582篇摘要，若摘要特别提及ACC和孕期，则检索其全文，包括原发性研究文章、综述、讨论论文和同行评审的书籍章节。我们排除了病例报告、会议和海报摘要、关于更广泛异常情况的论文以及动物研究。我们审阅了84篇全文文献，确定61篇纳入研究。
我们通过反复核对的过程，将数据按照位置、文章类型、研究设计、参与者年龄、ACC类型、招募情况、方法、工具/评估、结果、关键建议、诊断时的孕周、终止妊娠率、孤立性ACC的定义以及我们对文献的评论等标题进行整理。
我们根据主题排列的数据进行了叙述性综合分析。在纳入的文献中，ACC在妊娠17至38周被诊断出来，由于不同的病因、表现和结果，常被描述为异质性的。ACC是孤立存在还是伴有其他异常，被视为产前咨询的关键因素。然而，孤立性ACC的定义并不一致。
孤立性ACC的命名和定义不一致，增加了产前诊断的模糊性，在解释结果和诊断效果研究时必须予以考虑。目前缺乏关于ACC产前诊断对父母影响的研究，无法为整体护理干预和心理社会支持的提供提供参考。
