Postgraduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil.
Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Brazil.
J Ethnopharmacol. 2021 Jan 10;264:113181. doi: 10.1016/j.jep.2020.113181. Epub 2020 Jul 18.
Poincianella pyramidalis (Tul.) LP Queiroz (Fabaceae) is an endemic tree in the Northeast of Brazil. Its flowers, leaves, stem bark and root have been used over the years to treat infections, abdominal pain, inflammation, diarrhea, heartburn, and dyspepsia.
The present study is a critical assessment of the state-of-the-art concerning traditional uses, phytochemistry, pharmacology and toxicology of P. pyramidalis performed through the application of a robust research strategy to explore the therapeutic potential of P. pyramidalis extracts and isolated compounds for the treatment of human disorders.
Information related to this review was systematically collected from scientific literature databases for P. pyramidalis, including papers and patents (PubMed, Science Direct, Scopus, Web of Science, Google scholar, INPI, WIPO, EPO and USPTO), published books (e.g. Plantas Forrageiras das Caatingas), dissertations and theses. Plant taxonomy has been confirmed in the "The Plant List" database (www.theplantlist.org).
Phytochemical analysis of P. pyramidalis shows several constituents such as flavonoids, triterpenoids and phenylpropanoids. The extract and isolated constituents exhibited a wide range of in vitro and in vivo pharmacological effects including antimicrobial, antinociceptive, anti-inflammatory, gastroprotective and neuroprotective activities. In addition, toxicity studies showed that the administration of P. pyramidalis extract was safe in non-pregnant rats but displayed teratogenic effects in rats and goats. On the other hand, the search in patent databases reported a single filing, which highlights the disparity between a large number of published scientific articles versus the almost nonexistent filing of patents. This fact evidences a still little explored technological potential of the species.
P. pyramidalis represents an important therapeutic resource for the population from the Northeast of Brazil. Pharmacological studies confirmed the effectiveness of the extract or isolated compounds in the treatment of various pathologies traditionally treated with P. pyramidalis. The authors emphasize the need for in-depth research and future clinical trials in order to investigate the clinical efficacy and safety of P. pyramidalis.
Poincianella pyramidalis（Tul.）LP Queiroz（豆科）是巴西东北部的特有树种。多年来，其花、叶、茎皮和根一直被用于治疗感染、腹痛、炎症、腹泻、胃灼热和消化不良。
本研究通过应用稳健的研究策略，对 P. pyramidalis 的传统用途、植物化学、药理学和毒理学进行了全面评估，旨在探索 P. pyramidalis 提取物和分离化合物治疗人类疾病的治疗潜力。
从科学文献数据库中系统地收集了有关 P. pyramidalis 的信息，包括论文和专利（PubMed、Science Direct、Scopus、Web of Science、Google scholar、INPI、WIPO、EPO 和 USPTO）、出版书籍（如《Caatinga 饲料植物》）、论文和学位论文。植物分类学已在“植物名录”数据库（www.theplantlist.org）中得到确认。
P. pyramidalis 的植物化学分析表明存在多种成分，如类黄酮、三萜和苯丙素。提取物和分离成分表现出广泛的体外和体内药理作用，包括抗菌、镇痛、抗炎、胃保护和神经保护活性。此外，毒理学研究表明，在非妊娠大鼠中给予 P. pyramidalis 提取物是安全的，但在大鼠和山羊中显示出致畸作用。另一方面，专利数据库的检索报告仅提出了一项专利申请，这突出表明，与大量已发表的科学文章相比，专利申请几乎不存在，这表明该物种的技术潜力仍有待进一步探索。
P. pyramidalis 是巴西东北部居民的重要治疗资源。药理学研究证实，提取物或分离化合物在治疗传统上用 P. pyramidalis 治疗的各种疾病方面具有有效性。作者强调需要进行深入的研究和未来的临床试验，以调查 P. pyramidalis 的临床疗效和安全性。
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