Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran; Caspian Digestive Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Clin Nutr ESPEN. 2020 Aug;38:271-276. doi: 10.1016/j.clnesp.2020.03.022. Epub 2020 Apr 22.
One of the public health concerns is Vitamin D deficiency. The aim of this study was to determine the prevalence of vitamin D inadequacy and to determine its reproductive factor correlates in northern Iranian women.
This study, conducted on 5096 females aged 35-70 years. The study was based on data from PERSIAN Guilan Cohort Study (PGCS), a prospective, population-based cohort study in Guilan, Iran. History of reproductive and gynecologic factors, including age at menarche, age at first marriage, number of pregnancies or live births, age at first pregnancy, duration of breastfeeding, number of abortions, age and type of menopause status, use of oral contraceptives or hormone replacement therapy, history of hysterectomy, tubectomy or oophorectomy and history of gestational diabetes and hypertension was collected. Serum 25(OH) vitamin D was measured.
The mean 25(OH)-D concentration was 21.78 ng/mL, and 53.5% of women had vitamin D inadequacy. The multivariate analyses revealed that younger age (36-45 years) [>66 years adjusted odds ratio (aOR) = 2.1, 95% CI 1.7-2.7, 56-65 years aOR = 1.7, 95% CI 1.3-2.1 and 46-55 years aOR = 1.4, 95% CI 1.1-1.7], not consuming oral contraceptives [aOR = 1.1, 95% CI 1.05-1.3] and pre-menopausal status [aOR = 1.4, 95% CI 1.2-1.6] were significantly independently associated with vitamin D inadequacy.
Vitamin D inadequacy is common in northern Iranian women. The reproductive factors that independently correlated with vitamin D statues are oral contraceptive consumption and menopausal statue.
维生素 D 缺乏是公众健康关注的问题之一。本研究旨在确定伊朗北部女性维生素 D 不足的患病率，并确定其与生殖相关的因素。
本研究纳入了 5096 名年龄在 35-70 岁的女性。该研究基于伊朗吉兰前瞻性人群队列研究（PGCS）的数据。研究收集了与生殖和妇科相关的因素，包括初潮年龄、初婚年龄、妊娠或活产次数、初孕年龄、母乳喂养时间、流产次数、绝经年龄和类型、是否使用口服避孕药或激素替代疗法、是否接受过子宫切除术、输卵管结扎术或卵巢切除术、是否患有妊娠糖尿病和高血压。检测了血清 25(OH) 维生素 D 水平。
平均血清 25(OH)-D 浓度为 21.78ng/mL，53.5%的女性存在维生素 D 不足。多变量分析显示，年龄较轻（36-45 岁）[>66 岁调整后的优势比（aOR）=2.1，95%可信区间（CI）1.7-2.7；56-65 岁 aOR=1.7，95%CI 1.3-2.1；46-55 岁 aOR=1.4，95%CI 1.1-1.7]、不使用口服避孕药[aOR=1.1，95%CI 1.05-1.3]和未绝经[aOR=1.4，95%CI 1.2-1.6]与维生素 D 不足显著独立相关。
维生素 D 不足在伊朗北部女性中较为常见。与维生素 D 状态独立相关的生殖因素是口服避孕药的使用和绝经状态。
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