Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX.
MEDICORP My Family Doctor, Houston, TX.
Am J Med Sci. 2020 Dec;360(6):721-723. doi: 10.1016/j.amjms.2020.05.032. Epub 2020 May 28.
HIV elite controllers naturally suppress viral loads below limits of detection and evidence lack of evolution of infection for prolonged periods. The role of antiretroviral therapy (ART) in these individuals is controversial. Though recent data suggest that ART may decrease immune activation and prevent complications such as development of accelerated cardiovascular disease (CVD); treatment has not clearly demonstrated a benefit on clinical outcomes (e.g., HIV disease progression, CVD events, mortality). We describe a 49-year-old female HIV elite controller who presented with asymptomatic HIV infection for 26 years and review recent literature on the role of ART in this population.
HIV 精英控制者自然地将病毒载量抑制在检测限以下，并且有证据表明，在长时间内感染没有进化。抗逆转录病毒疗法 (ART) 在这些个体中的作用存在争议。尽管最近的数据表明，ART 可能会降低免疫激活并预防并发症，如加速心血管疾病 (CVD) 的发展；但治疗并未明确显示出对临床结果（例如 HIV 疾病进展、CVD 事件、死亡率）的益处。我们描述了一位 49 岁的女性 HIV 精英控制者，她无症状感染 HIV 已有 26 年，并回顾了关于 ART 在该人群中的作用的最新文献。
