Miyamura M, Hiruta S, Sakurai S, Ishida K, Saito M
Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan.
Tohoku J Exp Med. 1988 Dec;156 Suppl:125-35. doi: 10.1620/tjem.156.suppl_125.
In order to determine whether or not resting ventilatory response to hypercapnia is changed by physical training, we studied the effect of long-term physical training on the slope of ventilatory response to CO2 at rest. The subjects were 9 untrained freshmen ranging in age from 18 to 20 years. Five out of nine subjects belonged to the badminton team after entering university in April 1980, and participated in their team's training for about 3 hr per day, 3 times a week year round for about 4 years until March 1984. Maximum oxygen uptake (VO2max), maximum pulmonary ventilation (VEmax) and maximum heart rate (HR max) were determined during maximal treadmill exercise before and after training. The slope (S) of ventilatory response to carbon dioxide at rest was measured by Read's rebreathing method. VO2max increased after training in the trained subjects and mean values of VO2max which were measured in 1982, 1983, and 1984, were statistically higher than that of 1980. Similar tendency was observed in VEmax and VO2max/W. Average values and standard deviations of S before training were 1.91 +/- 0.52 liter/min/torr and were decreased gradually with increasing training period; the differences in the S value before (1980) and after training, i.e., 1982, 1983, and 1984, were all significant. Such difference could still be seen after S was recalculated as SN by using normalized ventilation for 70 kg body weight, while there were no significant differences in the S and SN between baseline and repeated studies in the untrained group. In addition, CO2 responsiveness was found to correlate negatively with maximum oxygen uptake in 4 out of the 5 trained subjects. These results suggest that in normal subjects, long-term physical training, as in the present study, decreases CO2 responsiveness at rest.
为了确定静息时对高碳酸血症的通气反应是否会因体育锻炼而改变，我们研究了长期体育锻炼对静息时二氧化碳通气反应斜率的影响。研究对象为9名年龄在18至20岁之间的未受过训练的大一新生。9名受试者中有5名在1980年4月进入大学后加入了羽毛球队，全年每周训练3次，每次约3小时，持续约4年，直至1984年3月。在训练前后的最大跑步机运动过程中测定最大摄氧量（VO2max）、最大肺通气量（VEmax）和最大心率（HR max）。静息时对二氧化碳的通气反应斜率（S）采用里德重复呼吸法测量。训练后，训练组受试者的VO2max增加，1982年、1983年和1984年测量的VO2max平均值在统计学上高于1980年。VEmax和VO2max/W也观察到类似趋势。训练前S的平均值和标准差为1.91±0.52升/分钟/托，并随着训练时间的增加而逐渐降低；训练前（1980年）和训练后（即1982年、1983年和1984年）的S值差异均具有统计学意义。在将S重新计算为SN（使用70公斤体重的标准化通气量）后，仍可看到这种差异，而未训练组在基线研究和重复研究之间的S和SN没有显著差异。此外，在5名训练组受试者中，有4名的二氧化碳反应性与最大摄氧量呈负相关。这些结果表明，在正常受试者中，如本研究中的长期体育锻炼会降低静息时的二氧化碳反应性。
