Yoshida M, Seki M, Aritomi T, Ishibashi M, Miyahara S
Second Department of Internal Medicine, School of Medicine, Fukuoka University.
Tohoku J Exp Med. 1988 Dec;156 Suppl:171-80.
The nature of ventilatory response to CO2 in patients with airway obstruction is controversial. Although the bronchodilating effect of aminophylline has been well documented, its effect on direct stimulation of breathing has not been systematically evaluated. Therefore, the effect of intravenous aminophylline on ventilatory response to CO2 of patients with asthma was studied by comparing with that of the healthy subjects. Ventilation (VE) at rest was not significantly different between in asthmatics and healthy subjects, and mouth occlusion pressures (P0.1) at rest was significantly higher in asthmatics than in healthy group (p less than 0.05). P0.1 after aminophylline increased significantly (p less than 0.05) compared to control value in asthmatics. Changes in VE and P0.1 relatively correlated well in both groups before and after aminophylline (r = 0.58). Ventilatory response to CO2 (VE/PA CO2) and P0.1 response to CO2 (P0.1/PACO2) in asthmatics were slightly increased, but not significantly different from those in the healthy group before and after aminophylline. These findings suggest that aminophylline might be effective in enhancing ventilatory response to CO2 in asthmatics than in healthy subjects, because of its bronchodilating effect and stimulation to the respiratory neurons.
气道阻塞患者对二氧化碳的通气反应性质存在争议。尽管氨茶碱的支气管舒张作用已有充分记录，但其对直接刺激呼吸的作用尚未得到系统评估。因此，通过与健康受试者进行比较，研究了静脉注射氨茶碱对哮喘患者二氧化碳通气反应的影响。哮喘患者和健康受试者静息时的通气量（VE）无显著差异，哮喘患者静息时的口腔阻断压（P0.1）显著高于健康组（p<0.05）。与哮喘患者的对照值相比，注射氨茶碱后的P0.1显著增加（p<0.05）。在注射氨茶碱前后，两组的VE和P0.1变化相对相关性良好（r=0.58）。哮喘患者对二氧化碳的通气反应（VE/PA CO2）和对二氧化碳的P0.1反应（P0.1/PACO2）略有增加，但在注射氨茶碱前后与健康组无显著差异。这些发现表明，由于氨茶碱的支气管舒张作用和对呼吸神经元的刺激作用，它可能比健康受试者更有效地增强哮喘患者对二氧化碳的通气反应。
