Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, 201203, China.
Chin J Integr Med. 2022 Sep;28(9):855-863. doi: 10.1007/s11655-020-3271-8. Epub 2020 Jul 20.
This article presented an overview of the therapeutic effects of Chinese medicine (CM) preparations for promoting blood circulation and removing blood stasis for patients with portal vein thrombosis (PVT) after splenectomy. Based on published clinical researches of CM preparations for PVT after splenectomy in patients with cirrhotic portal hypertension (CPH), this paper evaluated the incidence of PVT, and explored potential active components and mechanisms of CM preparations. Safflower Yellow Injection, Danshen Injection () Danhong Injection (), and Compound Danshen Dropping Pill () achieved good curative effect alone or combined with anticoagulant therapy. In addition, Compound Biejia Ruangan Tablet () and Anluo Huaxian Pill () can also significantly improve the hemodynamic disorders of portal vein system in patients with cirrhosis. Considering the role of CM preparations in ameliorating the incidence of PVT after splenectomy in patients with CPH, we suggested that future research should provide more attention to CM alone or CM combined with anticoagulant for cirrhosis with PVT.
本文综述了活血化瘀类中药制剂在预防肝硬化门静脉高压症(CPH)患者脾切除后门静脉血栓形成(PVT)中的应用。基于活血化瘀类中药制剂在预防肝硬化门静脉高压症患者脾切除后门静脉血栓形成中的临床研究,评估了 PVT 的发生率,并探讨了中药制剂的潜在活性成分和作用机制。红花黄色素注射液、丹参注射液、丹红注射液、复方丹参滴丸单独使用或联合抗凝治疗均取得了较好的疗效。此外,复方鳖甲软肝片和安络化纤丸也可显著改善肝硬化患者门静脉系统血流动力学紊乱。鉴于中药制剂在改善 CPH 患者脾切除后门静脉血栓形成发生率中的作用,我们建议未来的研究应更多地关注中药单独或中药联合抗凝治疗合并 PVT 的肝硬化患者。