正肝化瘀汤联合恩替卡韦对慢性乙型肝炎肝纤维化患者肠道菌群的影响。
Effects of Zhenggan Huayu decoction combined with entecavir on gut microbiota in patients with chronic hepatitis B fibrosis.
机构信息
Department of Liver Diseases, Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen 518172, China.
Department of Liver Diseases, Shenzhen Third People's Hospital, Guangdong 518112, China.
出版信息
J Tradit Chin Med. 2023 Jun;43(3):559-567. doi: 10.19852/j.cnki.jtcm.20230208.002.
OBJECTIVE
To evaluate the effects of Zhenggan Huayu decoction (, ZGHY) combined with entecavir (ETV) on the gut microbiota in patients with chronic hepatitis B (CHB) fibrosis.
METHODS
A total of 59 CHB-related fibrosis patients were enrolled and treated with ZGHY combined with ETV (ZGHY + ETV) and ETV alone. Fecal samples were collected from patients at weeks 0, 12, and 24 after treatment and gut microbiota were analyzed by 16S rRNA gene sequencing.
RESULTS
Compared to the ETV group, microbiota diversity in the ZGHY + ETV group was increased after 24 weeks. Some potentially pathogenic bacteria, including spp., spp., and spp. were reduced in the ZGHY + ETV group, while spp., spp., and several other beneficial bacteria were increased.
CONCLUSION
Decreases in pathogenic bacteria and increases in probiotics were not always observed in the Traditional Chinese Medicine (TCM) group (e.g., was abundant). As an adjuvant TCM formulation for ETV, ZGHY had a positive role in the treatment of CHB patients.
目的
评价正肝化瘀汤（ZGHY）联合恩替卡韦（ETV）对慢性乙型肝炎（CHB）纤维化患者肠道微生物群的影响。
方法
共纳入 59 例 CHB 相关纤维化患者，分别采用 ZGHY 联合 ETV（ZGHY+ETV）和 ETV 单独治疗。治疗后第 0、12、24 周采集患者粪便样本，采用 16S rRNA 基因测序分析肠道微生物群。
结果
与 ETV 组相比，ZGHY+ETV 组治疗 24 周后微生物多样性增加。一些潜在的致病菌，包括 spp.、spp.和 spp.，在 ZGHY+ETV 组中减少，而 spp.、spp.和其他几种有益菌增加。
结论
中药组（如 spp. 丰富）并不总是观察到致病菌减少和益生菌增加。作为 ETV 的辅助中药配方，ZGHY 对 CHB 患者的治疗有积极作用。
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