Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas, Campinas, SP, Brazil.
Faculty of Medicine, Pontifical Catholic University of Campinas, Campinas, SP, Brazil.
Epilepsy Behav. 2020 Oct;111:107318. doi: 10.1016/j.yebeh.2020.107318. Epub 2020 Jul 18.
The quality of life (QoL) perception over time in adult people with epilepsy (PWE) is important to define strategies of conduct.
The aim of this study was to assess the minimally important change (MIC) threshold of the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) of PWE over a period of 4 years and its relationship with clinical epilepsy variables.
A total of 129 PWE (46 ± 14.3 years) were included, and the clinical aspects of epilepsy and the QOLIE-31 were assessed in the initial and final assessment, with p < 0.05.
The emotional well-being (-6.31) and social functioning (-5.36) showed clinically relevant effects between the assessments. Quality of life was compromised by increasing the number of antiepileptic drugs (AED) taken [total score (-8.53), social functioning (-14.70)] or by maintaining the use of polytherapy [social functioning (-12.89)]. Fewer seizures were associated with a better QoL [total score (7.99), social (17.88) and cognitive functioning (16.30)]. The reduction in seizures was not associated with a better QoL [total and social functioning score], and the increase in seizures did not change QoL perception (cognitive functioning). There was a reduction in the QoL perception in medication effects in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) (8.92) and with an increase in age in one year (-0.44).
Quality of life was compromised in the emotional well-being and social functioning during the 4-year follow-up period. The increase in the number of AED taken and age and the TLE-HS compromised QoL changes in the frequency of seizures not associated with a significant improvement in QoL.
成人癫痫患者（PWE）随时间推移的生活质量（QoL）感知对于确定治疗策略很重要。
本研究旨在评估癫痫患者生活质量量表 31 项（QOLIE-31）在 4 年内 PWE 的最小重要变化（MIC）阈值及其与临床癫痫变量的关系。
共纳入 129 例 PWE（46±14.3 岁），在初始和最终评估中评估了癫痫的临床方面和 QOLIE-31，p＜0.05。
情绪健康（-6.31）和社会功能（-5.36）在评估之间显示出临床相关影响。抗癫痫药物（AED）的数量增加（总分（-8.53）、社会功能（-14.70））或维持多药治疗（社会功能（-12.89））会导致生活质量受损。发作次数减少与更好的 QoL 相关[总分（7.99）、社会（17.88）和认知功能（16.30）]。发作减少与更好的 QoL 无关[总分和社会功能评分]，发作增加不会改变 QoL 感知（认知功能）。在伴有海马硬化的颞叶癫痫（TLE-HS）（8.92）和年龄增加一年（-0.44）中，药物作用的 QoL 感知降低。
在 4 年随访期间，情绪健康和社会功能的生活质量受到损害。AED 数量的增加以及年龄的增加和 TLE-HS 与发作频率的变化相关，与 QoL 的显著改善无关。
