胰岛素治疗和运动对血管内皮的细胞和功能影响。
Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.
机构信息
Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.
出版信息
Curr Pharm Des. 2020;26(30):3760-3767. doi: 10.2174/1381612826666200721002735.
Abstract
Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium is also the barrier for insulin movement into tissues, it acts as a gatekeeper for transport and glucose uptake. For this reason, endothelial dysfunction is a tempting area for pharmacological and/or exercise intervention with insulin-based therapies. In this review, we describe the current state of drugs that can be used to treat endothelial dysfunction in type 2 diabetes and diabetes-related diseases (e.g., obesity) at the molecular levels, and also discuss their role in exercise.
摘要
内皮功能障碍是 2 型糖尿病的一个标志，它会对血管功能产生严重影响，包括高血压和血流变化，以及运动表现。因为内皮也是胰岛素进入组织的屏障，所以它是运输和葡萄糖摄取的守门员。出于这个原因，内皮功能障碍是一个有吸引力的领域，可以进行药理学和/或运动干预，以胰岛素为基础的治疗。在这篇综述中，我们描述了目前可用于治疗 2 型糖尿病和糖尿病相关疾病（如肥胖症）的药物在分子水平上的内皮功能障碍的状态，并讨论了它们在运动中的作用。
相似文献
1
Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.胰岛素治疗和运动对血管内皮的细胞和功能影响。
Curr Pharm Des. 2020;26(30):3760-3767. doi: 10.2174/1381612826666200721002735.
2
Diabetes pathogenesis and management: the endothelium comes of age.糖尿病发病机制与治疗：内皮细胞的时代来临。
J Mol Cell Biol. 2021 Oct 21;13(7):500-512. doi: 10.1093/jmcb/mjab024.
3
Reciprocal relationships between insulin resistance and endothelial dysfunction: insights from therapeutic interventions.胰岛素抵抗与内皮功能障碍之间的相互关系：治疗干预的见解
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun;31(3):305-12.
4
Extracellular Vesicles in Metabolic and Vascular Insulin Resistance.细胞外囊泡在代谢和血管胰岛素抵抗中的作用
J Vasc Res. 2024;61(3):129-141. doi: 10.1159/000538197. Epub 2024 Apr 12.
5
Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.胰岛素抵抗与内皮功能障碍之间的相互关系：分子和病理生理机制。
Circulation. 2006 Apr 18;113(15):1888-904. doi: 10.1161/CIRCULATIONAHA.105.563213.
6
Pioglitazone ameliorates endothelial dysfunction in those with impaired glucose regulation among the first-degree relatives of type 2 diabetes mellitus patients.吡格列酮可改善 2 型糖尿病患者一级亲属中葡萄糖调节受损者的内皮功能障碍。
Med Princ Pract. 2013;22(2):156-60. doi: 10.1159/000341770. Epub 2012 Sep 4.
7
Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications.食物多酚改善胰岛素抵抗和内皮功能障碍的机制：糖尿病及其心血管并发症的治疗意义。
Am J Physiol Endocrinol Metab. 2013 Sep 15;305(6):E679-86. doi: 10.1152/ajpendo.00377.2013. Epub 2013 Jul 30.
8
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.针对 VEGF-B 作为治疗胰岛素抵抗和 2 型糖尿病的新靶点。
Nature. 2012 Oct 18;490(7420):426-30. doi: 10.1038/nature11464. Epub 2012 Sep 26.
9
High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance.大剂量口服维生素C可部分补充2型糖尿病且维生素C水平较低患者的维生素C水平，但不能改善内皮功能障碍或胰岛素抵抗。
Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H137-45. doi: 10.1152/ajpheart.00768.2005. Epub 2005 Aug 26.
10
Improved endothelial function with metformin in type 2 diabetes mellitus.二甲双胍改善2型糖尿病患者的内皮功能。
J Am Coll Cardiol. 2001 Apr;37(5):1344-50. doi: 10.1016/s0735-1097(01)01129-9.
引用本文的文献
1
Issues on Trainability.可训练性问题。
Front Physiol. 2022 Jan 24;12:790196. doi: 10.3389/fphys.2021.790196. eCollection 2021.
2
Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction.肥胖诱导的内皮功能障碍中脂肪组织与内皮细胞的相互作用
Front Cardiovasc Med. 2021 Jul 1;8:681581. doi: 10.3389/fcvm.2021.681581. eCollection 2021.
本文引用的文献
1
Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.局部过氧亚硝酸盐损害肥胖症患者血管内皮瞬时受体电位香草酸 4 通道并升高血压。
Circulation. 2020 Apr 21;141(16):1318-1333. doi: 10.1161/CIRCULATIONAHA.119.043385. Epub 2020 Feb 3.
2
Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.短期连续和间歇运动训练对糖尿病前期患者内皮功能和葡萄糖代谢的影响。
J Diabetes Res. 2019 Dec 28;2019:4912174. doi: 10.1155/2019/4912174. eCollection 2019.
3
Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction.内皮 FTO 缺失拮抗肥胖诱导的代谢和血管功能障碍。
Circ Res. 2020 Jan 17;126(2):232-242. doi: 10.1161/CIRCRESAHA.119.315531. Epub 2019 Dec 5.
4
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial.二甲双胍可减弱老年人进行渐进性抗阻运动训练后的肌肉肥大：一项随机、双盲、安慰剂对照、多中心试验：MASTERS试验
Aging Cell. 2019 Dec;18(6):e13039. doi: 10.1111/acel.13039. Epub 2019 Sep 26.
5
Endothelial function following interval exercise plus low-calorie diet treatment in obese females.肥胖女性进行间歇运动加低热量饮食治疗后的内皮功能
Physiol Rep. 2019 Sep;7(18):e14239. doi: 10.14814/phy2.14239.
6
Exercise and the dipeptidyl-peptidase IV inhibitor sitagliptin do not improve beta-cell function and glucose homeostasis in long-lasting type 1 diabetes-A randomised open-label study.运动与二肽基肽酶IV抑制剂西他列汀对长期1型糖尿病患者β细胞功能及葡萄糖稳态无改善作用——一项随机开放标签研究
Endocrinol Diabetes Metab. 2019 May 23;2(3):e00075. doi: 10.1002/edm2.75. eCollection 2019 Jul.
7
Combined treatment of dipeptidyl peptidase-4 inhibitor and exercise training improves lipid profile in KK/Ta mice.二肽基肽酶-4抑制剂与运动训练联合治疗可改善KK/Ta小鼠的血脂水平。
Exp Physiol. 2019 Jul;104(7):1051-1060. doi: 10.1113/EP087449. Epub 2019 May 22.
8
Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.二甲双胍抑制老年人有氧运动训练中线粒体的适应性变化。
Aging Cell. 2019 Feb;18(1):e12880. doi: 10.1111/acel.12880. Epub 2018 Dec 11.
9
Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission.维达列汀通过抑制线粒体分裂改善高糖诱导的内皮线粒体功能障碍。
J Cell Mol Med. 2019 Feb;23(2):798-810. doi: 10.1111/jcmm.13975. Epub 2018 Nov 16.
10
Impact of short-term exercise training intensity on β-cell function in older obese adults with prediabetes.短期运动训练强度对老年肥胖前期糖尿病患者β细胞功能的影响。
J Appl Physiol (1985). 2018 Dec 1;125(6):1979-1986. doi: 10.1152/japplphysiol.00680.2018. Epub 2018 Oct 11.
Zotero 插件