Ota Yoshiaki, Masui Koji, Suzuki Gen, Yamazaki Hideya, Yamada Kei
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
J Contemp Brachytherapy. 2020 Jun;12(3):273-278. doi: 10.5114/jcb.2020.96870. Epub 2020 Jun 30.
To present a small series of cases, in which single-fraction image-guided high-dose-rate (HDR) brachytherapy was provided as palliative treatment for inoperable head and neck cancer cases.
We used this technique to treat 3 patients with symptomatic head and neck cancer (tongue cancer, gingival metastasis of osteosarcoma, and external auditory canal cancer), who were not eligible for a definitive treatment. The purpose of palliative brachytherapy in all 3 patients was the relief of symptoms such as difficulty in eating, talking, and hearing. All patients were treated with computed tomography (CT) image-guided interstitial HDR brachytherapy under local anesthesia in an outpatient setting, with a single dose of 10 Gy.
Satisfactory palliative effects were achieved in all cases without serious side effects. The palliative effects were sustained in 2 patients until death, and 1 patient lived for 39 weeks before a relapse.
Our palliative treatment technique appears to be safe, effective, and less invasive, and could be a treatment option for symptomatic patients with head and neck cancer.
介绍一小系列病例，其中单次分割图像引导高剂量率（HDR）近距离放射疗法被用作无法手术的头颈癌病例的姑息治疗。
我们使用该技术治疗了3例有症状的头颈癌患者（舌癌、骨肉瘤牙龈转移和外耳道癌），这些患者不符合确定性治疗的条件。所有3例患者姑息性近距离放射疗法的目的都是缓解诸如进食、说话和听力困难等症状。所有患者均在门诊局部麻醉下接受计算机断层扫描（CT）图像引导的间质HDR近距离放射疗法，单次剂量为10 Gy。
所有病例均取得了满意的姑息效果，且无严重副作用。2例患者的姑息效果持续至死亡，1例患者在复发前存活了39周。
我们的姑息治疗技术似乎安全、有效且侵入性较小，可能是有症状的头颈癌患者的一种治疗选择。
