Abdorubo A, Knoll J
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):673-83.
Studies on the response to tyramine of the rabbit pulmonal artery strip have revealed that several specific MAO-B inhibitors (TZ-650, J-580, AGN-1135, U-1424 MDL-72165 and Ro 16-6491) potentiated the responses in a dose-dependent manner, similarly as a semi-selective MAO-B inhibitor pargyline and a nonselective MAO inhibitor tranylcypromine did. Only (-)deprenyl inhibited the response. Thus the inhibition of noradrenaline-releasing effect of tyramine, a property favorable from the point of view of safety in clinical practice, is a specific feature of (-)deprenyl and not a more general characteristics of MAO-B inhibitors.
对兔肺动脉条对酪胺反应的研究表明，几种特定的单胺氧化酶B（MAO-B）抑制剂（TZ-650、J-580、AGN-1135、U-1424、MDL-72165和Ro 16-6491）以剂量依赖性方式增强反应，类似于半选择性MAO-B抑制剂优降宁和非选择性MAO抑制剂反苯环丙胺。只有（-）司来吉兰抑制该反应。因此，酪胺去甲肾上腺素释放效应的抑制是临床实践中安全性方面有利的特性，是（-）司来吉兰的一个特定特征，而非MAO-B抑制剂更普遍的特征。
