高葡萄糖在靶标识别和 thapsigargin 刺激时显著调节细胞毒性 T 淋巴细胞中的钙内流。
High glucose distinctively regulates Ca influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.
机构信息
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
出版信息
Eur J Immunol. 2020 Dec;50(12):2095-2098. doi: 10.1002/eji.202048577. Epub 2020 Aug 18.
PMID:32697355
Abstract
In CTLs: High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.
摘要
在 CTLs 中：高葡萄糖培养增强了 thapsigargin 诱导的 SOCE，但降低了靶识别诱导的 Ca2+内流。高葡萄糖培养调节 ORAIs 和 STIMs 的表达，而不影响葡萄糖摄取。更多经高葡萄糖培养的 CTLs 在执行杀伤后更容易发生坏死。
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