荟萃分析揭示转基因小鼠模型中慢性淋巴细胞白血病进展存在显著性别差异。
Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Transgenic Mouse Model.
作者信息
Koch Maximilian, Reinartz Sebastian, Saggau Julia, Knittel Gero, Rosen Natascha, Fedorchenko Oleg, Thelen Lisa, Barthel Romy, Reinart Nina, Seeger-Nukpezah Tamina, Reinhardt Hans Christian, Hallek Michael, Nguyen Phuong-Hien
机构信息
University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany.
Clinic for Hematology, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), 45147 Essen, Germany.
出版信息
Cancers (Basel). 2020 Jul 20;12(7):1980. doi: 10.3390/cancers12071980.
The transgenic mouse model represents the most widely and extensively used animal model for chronic lymphocytic leukemia (CLL). In this report, we performed a meta-analysis of leukemia progression in over 300 individual transgenic mice and discovered a significantly accelerated disease progression in females compared to males. This difference is also reflected in an aggressive CLL mouse model with additional deletion of besides the transgene. Moreover, after serial adoptive transplantation of murine CLL cells, female recipients also succumbed to CLL earlier than male recipients. This sex-related disparity in the murine models is markedly contradictory to the human CLL condition. Thus, due to our observation we urge both careful consideration in the experimental design and accurate description of the transgenic cohorts in future studies.
转基因小鼠模型是慢性淋巴细胞白血病（CLL）中使用最广泛、最深入的动物模型。在本报告中，我们对300多只个体转基因小鼠的白血病进展进行了荟萃分析，发现与雄性相比，雌性小鼠的疾病进展明显加快。这种差异也体现在一种除转基因外还存在额外缺失的侵袭性CLL小鼠模型中。此外，在对鼠CLL细胞进行连续过继移植后，雌性受体也比雄性受体更早死于CLL。小鼠模型中这种与性别相关的差异与人类CLL情况明显矛盾。因此，基于我们的观察，我们敦促在未来的研究中，在实验设计时要仔细考虑，并准确描述转基因队列。
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