Department of Virology, The Jikei University School of Medicine, Tokyo, Japan.
Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
Sci Rep. 2020 Jul 22;10(1):12217. doi: 10.1038/s41598-020-69248-9.
Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is associated with neurodegeneration through a comparison of AD, AD with cardiovascular disease (CVD), and vascular dementia (VaD). We measured blood COASY methylation levels in normal controls (NCs) (n = 200), and individuals with aMCI (n = 22), AD (n = 151), and VaD (n = 21). Compared with NCs, they were significantly higher in individuals with aMCI and AD. Further, they were significantly higher in AD patients without cardiovascular diseases compared to AD patients with them. These findings suggest that COASY methylation levels may be related to neurodegeneration in AD.
早期诊断包括阿尔茨海默病（AD）在内的痴呆症是一个紧迫的医学和福利问题。然而，迄今为止，还没有简单的生物标志物可用。我们报告称，编码辅酶 A 合酶的 COASY 基因的血液 DNA 甲基化水平在 AD 和遗忘型轻度认知障碍（aMCI）患者中升高。本研究旨在用更多的样本复制这些发现。另一个目的是通过比较 AD、AD 合并心血管疾病（CVD）和血管性痴呆（VaD）来阐明 COASY 甲基化是否与神经退行性变有关。我们测量了正常对照组（NC）（n=200）、aMCI 患者（n=22）、AD 患者（n=151）和 VaD 患者（n=21）的血液 COASY 甲基化水平。与 NC 相比，aMCI 和 AD 患者的 COASY 甲基化水平显著升高。此外，与有心血管疾病的 AD 患者相比，无心血管疾病的 AD 患者的 COASY 甲基化水平显著升高。这些发现表明，COASY 甲基化水平可能与 AD 中的神经退行性变有关。
