Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Sci Rep. 2020 Jul 22;10(1):12248. doi: 10.1038/s41598-020-68596-w.
This study investigates mosquito proboscis-inspired (MPI) insertion applied to the clinically used biopsy needle to reduce tissue deformation and organ displacement. Advanced medical imagining has enabled early-stage identification of cancerous lesions that require needle biopsy for minimally invasive tissue sampling and pathological analysis. Accurate cancer diagnosis depends on the accuracy of needle deployment to the targeted cancerous lesion site. However, currently available needle delivery systems deform and move soft tissue and organs, leading to a non-diagnostic biopsy or undersampling of the target. Two features inspired by the mosquito proboscis were adopted for MPI insertion in prostate biopsy: (1) the harpoon-shape notches at the needle tip and (2) reciprocating needle-cannula motions for incremental insertion. The local tissue deformation and global prostate displacement during the MPI vs. traditional direct insertions were quantified by optically tracking the displacement of particle-embedded tissue-mimicking phantoms. Results show that the MPI needle insertion reduced both local tissue deformation and global prostate displacement because of the opposite needle-cannula motions and notches which stabilized and reduced the tissue deformation during insertion. Findings provide proof of concept for MPI insertion in the clinical biopsy procedures as well as insights of needle-tissue interaction for future biopsy technology development.
本研究探讨了受蚊子口器启发的（MPI）插入应用于临床使用的活检针，以减少组织变形和器官移位。先进的医学成像技术使人们能够早期发现需要进行活检以进行微创组织取样和病理分析的癌性病变。准确的癌症诊断取决于将针准确部署到目标癌性病变部位的准确性。然而，目前可用的针输送系统会使软组织和器官变形和移动，导致非诊断性活检或目标组织采样不足。受蚊子口器启发，我们采用了两种特征来实现前列腺活检中的 MPI 插入：（1）针尖上的鱼叉形缺口，（2）用于渐进式插入的针套管往复运动。通过光学跟踪嵌入式粒子的组织模拟体的位移，定量评估了 MPI 与传统直接插入相比时的局部组织变形和全局前列腺位移。结果表明，MPI 针插入减少了局部组织变形和全局前列腺位移，因为反向的针套管运动和缺口稳定并减少了插入过程中的组织变形。研究结果为 MPI 插入在临床活检程序中的应用提供了概念验证，并为未来活检技术的发展提供了有关针组织相互作用的见解。
