DIAMIND M J, Brownstone Y S, Erceg G, Kieraszewicz H, Keeri-Szanto M
Can Anaesth Soc J. 1976 Mar;23(2):170-5. doi: 10.1007/BF03005688.
A clinical trial of castor oil in overdoses of lipophilic drugs gave a strong clinical impression that it was effective in speeding up recovery. Therefore, animal experiments were undertaken to confirm that castor oil acts as a ligand in Ethchlorvynol poisoning and that its use reduces coma time. Serial serum levels of Ethchlorvynol were obtained from dogs given Ethchlorvynol 150 mg/kg alone, and the same dose dissolved in castor oil 15 ml/kg in a crossover fashion. The result was a reduction of peak serum levels and of the half-life of the drug when the castor oil solution was used. In order to mimic the clinical situation more closely, a further crossover study was undertaken using Ethchlorvynol 300 mg/kg alone and the same dose followed by castor oil 15 ml/kg repeated q12h. This showed no delay in reaching peak serum concentration and no reduction of peak levels. However, it did show a 31 per cent reduction in the half-life of the drug. This change is statistically significant, and supports the continued use of castor oil in lipophilic drug overdose.
一项关于蓖麻油用于亲脂性药物过量的临床试验产生了强烈的临床印象，即它在加速康复方面是有效的。因此，进行了动物实验以证实蓖麻油在ethchlorvynol中毒中作为一种配体起作用，并且其使用可缩短昏迷时间。从单独给予150mg/kg ethchlorvynol的狗以及以交叉方式给予溶解在15ml/kg蓖麻油中的相同剂量ethchlorvynol的狗身上获取系列血清ethchlorvynol水平。结果是当使用蓖麻油溶液时，血清峰值水平和药物半衰期降低。为了更紧密地模拟临床情况，进行了另一项交叉研究，单独使用300mg/kg ethchlorvynol以及相同剂量后每12小时重复给予15ml/kg蓖麻油。这显示达到血清峰值浓度没有延迟且峰值水平没有降低。然而，它确实显示药物半衰期降低了31%。这种变化具有统计学意义，并支持在亲脂性药物过量中继续使用蓖麻油。
