Wang Peiyuan, Jiang Suhua, Li Yang, Luo Qiang, Lin Jinyan, Hu Lidan, Xu Congjian, Zhu Jun, Fan Lingling
Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, P. R. China.
Biomater Sci. 2020 Aug 21;8(16):4595-4602. doi: 10.1039/d0bm00678e. Epub 2020 Jul 23.
Solid tumor cells in hypoxic regions resist chemotherapy treatment with conventional antitumor drugs (such as paclitaxel, PTX) because the inadequate O attenuates the intracellular generation of reactive oxygen species (ROS) and upregulates multidrug resistance protein expression. Hyperbaric O therapy concentrates on improving O delivery to the hypoxic tumor area, thereby enhancing the sensitivity of cancer cells to chemotherapy drugs. However, the implementation of this therapy often elicits immune response or potentiates toxicity of the drugs toward normal cells. In this work, we successfully fabricated RBC-based micro-vehicles for precise hypoxia-activated O delivery under the 980 nm laser irradiation. Interestingly, the subsequent chemotherapy of PTX for ovarian tumors was significantly enhanced owing to the alleviation of hypoxia tumor microenvironment. Meanwhile, the RBC-based micro-vehicles have low side tissue effects, superior biocompatibility, and ultra-low immune response. Overall, the RBC-based drug delivery system holds a fascinating perspective towards O delivery for chemotherapy enhancement in other clinical solid malignancies.
缺氧区域的实体瘤细胞对传统抗肿瘤药物（如紫杉醇，PTX）的化疗具有抗性，因为氧不足会减弱细胞内活性氧（ROS）的生成并上调多药耐药蛋白的表达。高压氧疗法专注于改善向缺氧肿瘤区域的氧输送，从而增强癌细胞对化疗药物的敏感性。然而，这种疗法的实施常常引发免疫反应或增强药物对正常细胞的毒性。在这项工作中，我们成功制备了基于红细胞的微载体，用于在980 nm激光照射下实现精确的缺氧激活氧输送。有趣的是，由于缺氧肿瘤微环境的缓解，随后对卵巢肿瘤进行的PTX化疗显著增强。同时，基于红细胞的微载体具有低组织副作用、优异的生物相容性和超低的免疫反应。总体而言，基于红细胞的药物递送系统在为其他临床实体恶性肿瘤增强化疗的氧输送方面具有迷人的前景。
