Section of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Sciences, University of Catania, Catania, Italy.
National Council of Research, Institute for Biomedical Research and Innovation (IRIB), Unit of Catania, Catania, Italy.
J Child Adolesc Psychopharmacol. 2020 Nov;30(9):567-571. doi: 10.1089/cap.2020.0050. Epub 2020 Jul 17.
To report a case series of children presenting with episodes of abrupt onset psychotic symptoms presumably linked to pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS). Children/adolescents were selected among the group of individuals affected by clinical diagnosis of PANDAS/PANS. One group was selected by affected individuals coming from the Center UMDNJ-New Jersey Medical School, New Jersey, USA and the other from the Department of Pediatrics Catania University, Italy. Child health Questionnaire Parent form 50 was given to parents to describe children's quality of life. Among the group of individuals with PANDAS/PANS disorders, eight children/adolescents were selected, six coming from the UMDNJ-New Jersey and two from Catania, University centers showing among the other typical manifestations severe episodes of abrupt onset of psychotic symptoms. Severe psychotic symptoms may be considered one among the other neuropsychiatric clinical manifestations presenting in individuals with PANDAS/PANS syndromes.
报告一系列儿童病例，这些儿童出现突发性精神病症状，可能与链球菌感染相关的儿科自身免疫性神经精神障碍（PANDAS）和儿科急性发作性神经精神综合征（PANS）有关。这些儿童/青少年是从 PANDAS/PANS 临床诊断影响的人群中选择出来的。一组是从美国新泽西州 UMDNJ-新泽西医学院的受影响个体中选择的，另一组是从意大利卡塔尼亚大学儿科系选择的。父母用儿童健康问卷 50 对孩子的生活质量进行了描述。在 PANDAS/PANS 障碍人群中，选择了 8 名儿童/青少年，其中 6 名来自 UMDNJ-新泽西，2 名来自卡塔尼亚大学中心，这些中心除了表现出典型的严重突发性精神病症状外。严重的精神病症状可能被认为是 PANDAS/PANS 综合征患者出现的其他神经精神临床表现之一。
