• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

准备暴露前预防措施。

PrEParing for Preexposure Prophylaxis.

机构信息

University of Southern California, Los Angeles, California

Carlow University, Pittsburgh, Pennsylvania.

出版信息

J Dr Nurs Pract. 2020 Mar 1;13(1):3-8. doi: 10.1891/2380-9418.JDNP-D-19-00033. Epub 2020 Jan 27.

DOI:10.1891/2380-9418.JDNP-D-19-00033
PMID:32701461
Abstract

BACKGROUND

In 2012 the Food and Drug Administration (FDA) approved Truvada (emtricitabine [FTC] 200 mg/tenofovir disoproxil fumarate [TDF] 300 mg) for preexposure prophylaxis (PrEP) against HIV. There was a substantial decline in new HIV diagnoses which has since stabilized.

OBJECTIVE

The plateau is thought to be because preventative efforts are not reaching high-risk groups. About 1.2 million adults in the United States could benefit from PrEP but only 80,000 individuals are taking it. This article aims to increase provider awareness of PrEP so primary care providers feel confident discussing risk reduction options, initiating, and monitoring PrEP.

METHODS

A case based approached is used to achieve the objective.

RESULTS

Target populations, baseline labs, follow up labs and monitoring parameters, and side effects of medication will be reviewed. Patient counseling with regards to dosing, administration, side effects and adverse events will be discussed.

CONCLUSIONS

HIV prevention is an integral public health goal. PrEP is a way to achiveeve continued reduction in HIV incidence. PCPs should be offering PrEP to at risk individuals.

IMPLICATIONS FOR NURSING

Many nurse practitioners work as primary care providers, this article hopes to increase the confidence of PCPs in prescribing PrEP to those who would benefit from it.

摘要

背景

2012 年,食品和药物管理局(FDA)批准了特鲁瓦达(恩曲他滨[FTC]200mg/替诺福韦二吡呋酯[TDF]300mg)用于 HIV 暴露前预防(PrEP)。新的 HIV 诊断病例数量大幅下降,此后趋于稳定。

目的

人们认为这一稳定态势是因为预防工作没有覆盖到高风险群体。在美国,大约有 120 万成年人可以从 PrEP 中受益,但只有 8 万人在服用。本文旨在提高医务人员对 PrEP 的认识,使初级保健提供者有信心讨论减少风险的选择、启动和监测 PrEP。

方法

采用基于案例的方法来实现这一目标。

结果

将回顾目标人群、基线实验室检查、随访实验室检查和监测参数以及药物的副作用。将讨论与剂量、给药、副作用和不良事件有关的患者咨询。

结论

艾滋病毒预防是公共卫生的一个重要目标。PrEP 是实现 HIV 发病率持续下降的一种方法。初级保健提供者应向高危人群提供 PrEP。

对护理的意义

许多执业护士担任初级保健提供者,本文希望提高初级保健提供者为那些受益于 PrEP 的人开处方 PrEP 的信心。

相似文献

1
PrEParing for Preexposure Prophylaxis.准备暴露前预防措施。
J Dr Nurs Pract. 2020 Mar 1;13(1):3-8. doi: 10.1891/2380-9418.JDNP-D-19-00033. Epub 2020 Jan 27.
2
Low Disclosure of PrEP Nonadherence and HIV-Risk Behaviors Associated With Poor HIV PrEP Adherence in the HPTN 067/ADAPT Study.在 HPTN 067/ADAPT 研究中,与 HIV 暴露前预防(PrEP)低依从性相关的 HIV 风险行为披露率低,与 HIV 暴露前预防(PrEP)低依从性相关。
J Acquir Immune Defic Syndr. 2019 Sep 1;82(1):34-40. doi: 10.1097/QAI.0000000000002103.
3
Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement.HIV 感染预防的暴露前预防:美国预防服务工作组推荐声明。
JAMA. 2019 Jun 11;321(22):2203-2213. doi: 10.1001/jama.2019.6390.
4
Should we fear resistance from tenofovir/emtricitabine preexposure prophylaxis?我们应该担心替诺福韦/恩曲他滨暴露前预防产生的耐药性吗?
Curr Opin HIV AIDS. 2016 Jan;11(1):49-55. doi: 10.1097/COH.0000000000000209.
5
Evaluating statewide HIV preexposure prophylaxis implementation using All-Payer Claims Data.利用全民医保理赔数据评估全州范围内 HIV 暴露前预防的实施情况。
Ann Epidemiol. 2020 Apr;44:1-7.e2. doi: 10.1016/j.annepidem.2020.03.003. Epub 2020 Mar 26.
6
Daily or on-demand oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis: experience from a hospital-based clinic in France.每日或按需口服替诺福韦地索普西酯/恩曲他滨用于 HIV 暴露前预防:来自法国一家医院诊所的经验。
AIDS. 2018 Sep 24;32(15):2161-2169. doi: 10.1097/QAD.0000000000001939.
7
Preexposure Prophylaxis for Prevention of HIV Acquisition Among Adolescents: Clinical Considerations, 2020.青少年艾滋病预防的暴露前预防:临床考虑因素,2020 年。
MMWR Recomm Rep. 2020 Apr 24;69(3):1-12. doi: 10.15585/mmwr.rr6903a1.
8
Oral preexposure prophylaxis to prevent HIV infection: clinical and public health implications.口服暴露前预防以预防HIV感染:临床及公共卫生意义
JAAPA. 2014 Dec;27(12):10-7. doi: 10.1097/01.JAA.0000456567.37724.e0.
9
Review of Real-World Implementation Data on Emtricitabine-Tenofovir Disoproxil Fumarate as HIV Pre-exposure Prophylaxis in the United States.美国恩曲他滨替诺福韦二吡呋酯用于 HIV 暴露前预防的真实世界实施数据回顾。
Pharmacotherapy. 2019 Apr;39(4):486-500. doi: 10.1002/phar.2240. Epub 2019 Apr 1.
10
Barriers to the Wider Use of Pre-exposure Prophylaxis in the United States: A Narrative Review.美国广泛使用暴露前预防措施的障碍:叙事性综述。
Adv Ther. 2020 May;37(5):1778-1811. doi: 10.1007/s12325-020-01295-0. Epub 2020 Mar 30.