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心室辅助装置植入和减肥手术:病态肥胖终末期心力衰竭患者移植的途径。

Ventricular Assist Device Implantation and Bariatric Surgery: A Route to Transplantation in Morbidly Obese Patients with End-Stage Heart Failure.

机构信息

From the Division of Thoracic and Cardiovascular Surgery, College of Medicine, University of Florida, Gainesville, FL.

Division of Minimally Invasive Surgery, College of Medicine, University of Florida, Gainesville, FL.

出版信息

ASAIO J. 2021 Feb 1;67(2):163-168. doi: 10.1097/MAT.0000000000001212.

Abstract

We reviewed our experience of morbidly obese patients with end-stage heart failure that underwent left ventricular assist device (LVAD) implantation. From January 1, 2008 to January 1, 2018, 240 adult LVADs were implanted at our center. We reviewed the cases of patients presenting with end-stage heart failure and morbid obesity (preoperative body mass index [BMI] ≥ 35 kg/m2) who underwent LVAD-alone, and compared that to a group that underwent LVAD and bariatric surgery (laparoscopic sleeve gastrectomy [LSG]) as a means for weight reduction. Demographic characteristics, perioperative details, BMI, and status of transplant candidacy were recorded. Statistical analysis was performed (SPSS version 25) with χ2 analysis, Kaplan-Meier survival analysis, regression analysis, and Student's t-test. Twenty-nine patients met criteria and underwent LVAD implantation. Fifteen patients underwent LVAD-alone. Fourteen patients underwent LVAD + LSG. Both groups showed good survival outcomes, LVAD-alone (88.9 ± 5.9 months) versus LVAD +LSG (96.1 ± 12.4 months) but were not significantly different. However, we did note that more patients in the LVAD + LSG group were bridged to heart transplantation (p < 0.001). LVAD-alone and/or LVAD + LSG are both technically feasible and effective treatment options for the long-term survival of morbidly obese patients with end-stage heart failure. Combining LVAD + LSG can help bridge patients to heart transplantation.

摘要

我们回顾了我们在接受左心室辅助装置(LVAD)植入的病态肥胖终末期心力衰竭患者方面的经验。从 2008 年 1 月 1 日至 2018 年 1 月 1 日,我们中心共植入了 240 例成人 LVAD。我们回顾了患有终末期心力衰竭和病态肥胖(术前体重指数[BMI]≥35kg/m2)的患者的病例,这些患者接受了 LVAD 单独治疗,并将其与接受 LVAD 和减肥手术(腹腔镜袖状胃切除术[LSG])的患者进行了比较。记录了人口统计学特征、围手术期细节、BMI 和移植候选状态。采用 χ2 分析、Kaplan-Meier 生存分析、回归分析和学生 t 检验进行统计分析(SPSS 版本 25)。29 名患者符合标准并接受了 LVAD 植入。15 名患者接受了 LVAD 单独治疗。14 名患者接受了 LVAD+LSG。两组均显示出良好的生存结果,LVAD 单独治疗组(88.9±5.9 个月)与 LVAD+LSG 组(96.1±12.4 个月)相似,但无统计学差异。然而,我们确实注意到,LVAD+LSG 组中有更多的患者桥接进行心脏移植(p<0.001)。LVAD 单独治疗和/或 LVAD+LSG 都是病态肥胖终末期心力衰竭患者长期生存的可行且有效的治疗选择。LVAD+LSG 的联合应用可以帮助患者桥接进行心脏移植。

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