牙周病与男性不育症的关系：病例对照研究。

Relationship between periodontal disease and male infertility: A case-control study.

机构信息

Department of Preventive Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Oral Dis. 2021 Apr;27(3):624-631. doi: 10.1111/odi.13552. Epub 2020 Aug 31.

DOI:10.1111/odi.13552

PMID:32702140

Abstract

OBJECTIVES

To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study.

MATERIALS AND METHODS

Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities were included in the case group. The control group was composed of patients of the same clinic with normozoospermia. The semen analysis included sperm concentration, count and progressive and total motility, which were measured in the laboratory. A questionnaire and clinical periodontal examination were conducted for all participants. Logistic regression was performed to explore the relationship between chronic periodontitis and male infertility.

RESULTS

A total of 192 participants were included: 63 participants (32.8%) had some type of semen abnormality (case group), while 129 participants (67.2%) had normozoospermia (control group). The case group had a significantly higher prevalence of moderate/severe periodontitis than the control group (33.3% vs. 17.8%, p = .012). The logistic regression showed that participants who had moderate/severe periodontitis had a greater chance of having semen abnormalities after adjusting for other confounding factors (OR = 3.377, p = .005).

CONCLUSIONS

Periodontitis is associated with semen abnormalities and sperm motility in men.

摘要

目的

通过病例对照研究比较精液异常男性和正常精子男性慢性牙周炎的患病率。

材料与方法

将就诊于一家大型综合医院辅助生殖科且被诊断为精液异常的男性患者纳入病例组。对照组由同一诊所具有正常精子的患者组成。精液分析包括精子浓度、计数以及前向运动和总运动能力，这些指标均在实验室进行测量。所有参与者都接受了问卷调查和临床牙周检查。采用 logistic 回归分析探讨慢性牙周炎与男性不育之间的关系。

结果

共纳入 192 名参与者：63 名参与者（32.8%）存在某种类型的精液异常（病例组），而 129 名参与者（67.2%）具有正常精子（对照组）。病例组中中重度牙周炎的患病率显著高于对照组（33.3% vs. 17.8%，p=0.012）。logistic 回归分析显示，在调整其他混杂因素后，患有中重度牙周炎的参与者精液异常的可能性更大（OR=3.377，p=0.005）。