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1
Control of ram sperm adenylate cyclase by divalent cations.二价阳离子对公羊精子腺苷酸环化酶的调控
Aust J Biol Sci. 1988;41(3):377-85. doi: 10.1071/bi9880377.
2
The effect of divalent cations on bovine spermatozoal adenylate cyclase activity.二价阳离子对牛精子腺苷酸环化酶活性的影响。
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Adenylate cyclase activity increases concomitantly with the onset of capacitation in heparin-treated bovine spermatozoa.在肝素处理的牛精子中，腺苷酸环化酶活性随着获能的开始而同步增加。
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EGTA-sensitive and -insensitive forms of particulate adenylate cyclase in rat cerebral cortex: regulation by divalent cations and GTP.大鼠大脑皮层中对乙二醇双（2-氨基乙基醚）四乙酸（EGTA）敏感和不敏感的颗粒型腺苷酸环化酶形式：二价阳离子和鸟苷三磷酸（GTP）的调节作用
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The sperm adenylate cyclase.精子腺苷酸环化酶。
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A model for the regulation of brain adenylate cyclase by ionic equilibria.一种通过离子平衡调节脑腺苷酸环化酶的模型。
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Differentiation of fluorides-stimulated and non-fluoride-stimulated components of beef brain cortex adenylate cyclase cy calcium ions, ethyleneglycol-bis-(beta-aminoethyl ether) N,N'-tetraacetic acid and Triton X-100.牛肉脑皮质腺苷酸环化酶的氟化物刺激成分与非氟化物刺激成分在钙离子、乙二醇双（β-氨基乙醚）N，N'-四乙酸和曲拉通X-100作用下的分化。
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引用本文的文献

1
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes.细菌和真核生物中碳酸氢盐调节的“可溶性”腺苷酸环化酶功能域结构的保守性。
Dev Genes Evol. 2004 Oct;214(10):503-9. doi: 10.1007/s00427-004-0432-2. Epub 2004 Aug 20.

二价阳离子对公羊精子腺苷酸环化酶的调控

Control of ram sperm adenylate cyclase by divalent cations.

作者信息

Goh P P, White I G

机构信息

Department of Veterinary Physiology, University of Sydney, N.S.W.

出版信息

Aust J Biol Sci. 1988;41(3):377-85. doi: 10.1071/bi9880377.

DOI:10.1071/bi9880377
PMID:3270503
Abstract

The adenylate cyclase activity of ram sperm increased on freeze-thawing and the enzyme was stable at 0 degrees C. Its activity was stimulated by Mn2+, Zn2+, Co2+, Mg2+ and Ca2+ in descending order of activity. The enzyme was insensitive to fluoride when Mn2+ concentration was in excess. Mn2+-stimulated enzyme activity was decreased by the simultaneous addition of Co2+, or Cd2+, or Ni2+, and particularly Cu2+. Sulfhydryl compounds (viz. dithiothreitol, glutathione, dithiocarbamate, 2-mercaptoethanol, ergothioneine and cysteine) and chelating agents (viz. D-penicillamine and 8-hydroxyquinoline) were effective, to varying degrees, in overcoming the inhibition by Cu2+. Ca2+ augmented the stimulatory effect of Mg2+, Co2+, Zn2+ and Mn2+ on enzyme activity.

摘要

公羊精子的腺苷酸环化酶活性在冻融后增加，且该酶在0℃时稳定。其活性受到Mn2+、Zn2+、Co2+、Mg2+和Ca2+的刺激，活性顺序递减。当Mn2+浓度过量时，该酶对氟化物不敏感。同时添加Co2+、Cd2+、Ni2+，尤其是Cu2+时，Mn2+刺激的酶活性会降低。巯基化合物（即二硫苏糖醇、谷胱甘肽、二硫代氨基甲酸盐、2-巯基乙醇、麦角硫因和半胱氨酸）和螯合剂（即D-青霉胺和8-羟基喹啉）在不同程度上有效克服Cu2+的抑制作用。Ca2+增强了Mg2+、Co2+、Zn2+和Mn2+对酶活性的刺激作用。