Coulter A W, Bueding E, Batzinger R P
J Med Chem. 1977 Jul;20(7):981-2. doi: 10.1021/jm00217a029.
While 4-isothiocyano-4'-nitrodiphenylamine has high schistosomicidal activity in vivo and is devoid of mutagenic properties in vitro, the reverse is true for the isocyano analogue of this compound; i.e., replacement of the sulfur by oxygen results in a compound that has no demonstrable antischistosomal effects and exhibits significant mutagenic activity.
虽然4-异硫氰酸基-4'-硝基二苯胺在体内具有高杀血吸虫活性且在体外无诱变特性，但该化合物的异氰酸类似物情况则相反；即，用氧取代硫会产生一种没有明显抗血吸虫作用且具有显著诱变活性的化合物。
