Ma Fengtao, Wo Yeqianli, Li Hongyang, Chang Meinan, Wei Jingya, Zhao Shengguo, Sun Peng
State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Animals (Basel). 2020 Jul 22;10(8):1246. doi: 10.3390/ani10081246.
Zinc is considered to be an anti-diarrheal agent, and it may therefore reduce the incidence of diarrhea in young calves. In the present study, we aimed to compare the effect of zinc source on growth performance, the incidence of diarrhea, tissue zinc accumulation, the expression of zinc transporters, and the serum concentrations of zinc-dependent proteins in neonatal Holstein dairy calves. Eighteen male newborn Holstein dairy calves were fed milk and starter diet supplemented with or without 80 mg zinc/d in the form of Zn-Met or ZnO for 14 days, and were then euthanized. Zn-Met supplementation improved average daily gain and feed efficiency, and reduced the incidence of diarrhea, compared with control calves ( < 0.05). It also increased the serum and hepatic zinc concentrations and the mRNA expression of the ZIP4 transporter in the jejunal mucosa of the calves ( < 0.05). In addition, the serum alkaline phosphatase activity and metallothionein concentration were higher in Zn-Met-treated calves than in control calves ( < 0.05). ZnO supplementation had similar effects, but these did not reach significance. Thus, Zn-Met supplementation is an effective means of increasing tissue zinc accumulation and jejunal zinc absorption, and can be used as an anti-diarrheal strategy in neonatal calves.
锌被认为是一种抗腹泻剂，因此它可能会降低犊牛腹泻的发生率。在本研究中，我们旨在比较锌源对新生荷斯坦奶牛犊生长性能、腹泻发生率、组织锌蓄积、锌转运蛋白表达以及锌依赖性蛋白血清浓度的影响。18头雄性新生荷斯坦奶牛犊喂食添加或不添加80毫克/天以蛋氨酸锌或氧化锌形式存在的锌的牛奶和开食料，持续14天，然后实施安乐死。与对照犊牛相比，补充蛋氨酸锌提高了平均日增重和饲料效率，并降低了腹泻发生率（<0.05）。它还增加了犊牛血清和肝脏中的锌浓度以及空肠黏膜中ZIP4转运蛋白的mRNA表达（<0.05）。此外，补充蛋氨酸锌的犊牛血清碱性磷酸酶活性和金属硫蛋白浓度高于对照犊牛（<0.05）。补充氧化锌有类似效果，但未达到显著水平。因此，补充蛋氨酸锌是增加组织锌蓄积和空肠锌吸收的有效手段，可作为新生犊牛的抗腹泻策略。
