Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Department of Physics and Earth Sciences, University of Ferrara, Via Giuseppe Saragat 1, 44122 Ferrara, Italy.
Molecules. 2020 Jul 22;25(15):3331. doi: 10.3390/molecules25153331.
The present work focused on the use of high-silica commercial zeolites as sorbent media for pharmaceuticals in an aqueous matrix. As drug probes, ketoprofen, hydrochlorothiazide, and atenolol were selected, because of their occurrence in surface waters and effluents from wastewater treatment plants. Pharmaceuticals adsorption was evaluated for two Faujasite topology zeolites with Silica/Alumina Ratio 30 and 200. The selected zeolites were demonstrated to be efficient sorbents towards all investigated pharmaceuticals, thanks to their high saturation capacities (from 12 to 32% w/w) and binding constants. These results were corroborated by thermal and structural analyses, which revealed that adsorption occurred inside zeolite's porosities, causing lattice modifications. Finally, zeolites have been tested as a pre-concentration media in the dispersive-solid phase extraction procedure. Recoveries higher than 95% were gained for ketoprofen and hydrochlorothiazide and approximately 85% for atenolol, at conditions that promoted the dissolution of the neutral solute into a phase mainly organic. The results were obtained by using a short contact time (5 min) and reduced volume of extraction (500 µL), without halogenated solvents. These appealing features make the proposed procedure a cost and time saving method for sample enrichment as well as for the regeneration of exhausted sorbent, rather than the more energetically expensive thermal treatment.
本工作重点研究了高硅商业沸石作为水基中药物的吸附剂。以酮洛芬、氢氯噻嗪和阿替洛尔作为药物探针，因为它们存在于地表水和污水处理厂废水中。评估了两种具有硅铝比 30 和 200 的丝光沸石拓扑结构沸石对所有研究药物的吸附性能。所选沸石对所有研究药物均表现出高效的吸附能力，这得益于其高饱和容量（12%至 32%w/w）和结合常数。这些结果得到了热和结构分析的证实，表明吸附发生在沸石的孔隙内，导致晶格发生变化。最后，沸石被测试为分散固相萃取程序中的预浓缩介质。在促进中性溶质溶解到主要为有机相的条件下，酮洛芬和氢氯噻嗪的回收率高于 95%，阿替洛尔的回收率约为 85%。通过使用短接触时间（5 分钟）和减少萃取体积（500µL），且不使用卤代溶剂，获得了这些结果。这些有吸引力的特点使得所提出的方法成为一种节省成本和时间的样品富集方法，以及用于再生耗尽的吸附剂的方法，而不是更耗能的热解吸方法。
