Palliative care, St Luke's Hospice, Sheffield, UK
Palliative care, St Luke's Hospice, Sheffield, UK.
BMJ Support Palliat Care. 2020 Sep;10(3):316-317. doi: 10.1136/bmjspcare-2019-002172. Epub 2020 Jul 24.
Opioid-induced constipation (OIC) is common and can significantly affect quality of life. Naloxegol and methylnaltrexone are peripherally acting µ-opioid receptor antagonists (PAMORAs) which are effective for the management of OIC. We report on a case in the palliative care setting where a patient with established OIC had an inadequate response to naloxegol but an effective and immediate response to methylnaltrexone at the dose recommended for her weight. This is the first reported case of two PAMORAs used concomitantly.
阿片类药物引起的便秘（OIC）很常见，会显著影响生活质量。纳洛酮和甲基纳曲酮是外周作用μ-阿片受体拮抗剂（PAMORAs），可有效治疗 OIC。我们报告了 1 例在姑息治疗环境中，患有 OIC 的患者对纳洛酮反应不足，但对推荐体重剂量的甲基纳曲酮有有效且即刻的反应。这是首例同时使用两种 PAMORAs 的报道。
