Department of Ultrasonography, Harbin Medical University Cancer Hospital, 150 Haping Road, 150040, Harbin, China.
Cell Death Dis. 2020 Jul 24;11(7):580. doi: 10.1038/s41419-020-02772-8.
Cancer progression including proliferation, metastasis, and chemoresistance has become a serious hindrance to cancer therapy. This phenomenon mainly derives from the innate insensitive or acquired resistance of cancer cells to apoptosis. Ferroptosis is a newly discovered mechanism of programmed cell death characterized by peroxidation of the lipid membrane induced by reactive oxygen species. Ferroptosis has been confirmed to eliminate cancer cells in an apoptosis-independent manner, however, the specific regulatory mechanism of ferroptosis is still unknown. The use of ferroptosis for overcoming cancer progression is limited. Noncoding RNAs have been found to play an important roles in cancer. They regulate gene expression to affect biological processes of cancer cells such as proliferation, cell cycle, and cell death. Thus far, the functions of ncRNAs in ferroptosis of cancer cells have been examined, and the specific mechanisms by which noncoding RNAs regulate ferroptosis have been partially discovered. However, there is no summary of ferroptosis associated noncoding RNAs and their functions in different cancer types. In this review, we discuss the roles of ferroptosis-associated noncoding RNAs in detail. Moreover, future work regarding the interaction between noncoding RNAs and ferroptosis is proposed, the possible obstacles are predicted and associated solutions are put forward. This review will deepen our understanding of the relationship between noncoding RNAs and ferroptosis, and provide new insights in targeting noncoding RNAs in ferroptosis associated therapeutic strategies.
癌症的进展包括增殖、转移和化疗耐药性，已成为癌症治疗的严重障碍。这种现象主要源于癌细胞对细胞凋亡的固有不敏感或获得性耐药。铁死亡是一种新发现的程序性细胞死亡机制，其特征是活性氧诱导的脂质膜过氧化。铁死亡已被证实能够以不依赖细胞凋亡的方式消除癌细胞，然而，铁死亡的确切调节机制仍不清楚。利用铁死亡来克服癌症进展的应用受到限制。非编码 RNA 已被发现在癌症中发挥重要作用。它们调节基因表达，影响癌细胞的生物过程，如增殖、细胞周期和细胞死亡。迄今为止，已经研究了 ncRNA 在癌细胞铁死亡中的作用，并且部分发现了非编码 RNA 调节铁死亡的具体机制。然而，目前尚无关于铁死亡相关非编码 RNA 及其在不同癌症类型中的功能的综述。在这篇综述中，我们详细讨论了铁死亡相关非编码 RNA 的作用。此外，还提出了关于非编码 RNA 与铁死亡相互作用的未来工作，预测了可能的障碍并提出了相关的解决方案。这篇综述将加深我们对非编码 RNA 与铁死亡之间关系的理解，并为靶向铁死亡相关治疗策略中的非编码 RNA 提供新的见解。
