Zhang Yuan, Zhang Jingjing, Chen Sirui, Li Mianxin, Yang Jin, Tan Jingsi, He Binsheng, Zhu Lemei
Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha 410219, People's Republic of China.
School of Stomatology, Changsha Medical University, Changsha 410219, People's Republic of China.
Int J Womens Health. 2024 Sep 30;16:1633-1651. doi: 10.2147/IJWH.S485653. eCollection 2024.
Non-coding RNAs (ncRNAs) are transcripts originating from the genome that do not serve as templates for protein synthesis. They function as epigenetic and translational regulators in various pathophysiological mechanisms, including cell proliferation and apoptosis. The ferroptosis signaling pathway, a novel mode of cell death, participates in numerous pathophysiological processes. Its signaling transmission is both complex and precise, featuring interconnected and interdependent pathways. Recent studies suggest that ncRNAs can finely regulate key genes in the ferroptosis pathway, thus modulating cellular functions, reducing oxidative stress, and maintaining maternal-fetal interface homeostasis. Future strategies targeting the ncRNA/ferroptosis axis may provide new perspectives and potential intervention points for treating preeclampsia. This article clarifies how the ncRNA/ferroptosis axis impacts preeclampsia, revealing how ncRNAs interact with ferroptosis, and pinpointing new molecular targets for the treatment of preeclampsia, thereby providing theoretical support for clinical strategies.
非编码RNA（ncRNAs）是源自基因组的转录本，不作为蛋白质合成的模板。它们在各种病理生理机制中作为表观遗传和翻译调节因子发挥作用，包括细胞增殖和凋亡。铁死亡信号通路是一种新的细胞死亡模式，参与众多病理生理过程。其信号传递既复杂又精确，具有相互连接和相互依赖的途径。最近的研究表明，ncRNAs可以精细调节铁死亡途径中的关键基因，从而调节细胞功能、降低氧化应激并维持母胎界面的稳态。针对ncRNA/铁死亡轴的未来策略可能为治疗子痫前期提供新的视角和潜在的干预点。本文阐明了ncRNA/铁死亡轴如何影响子痫前期，揭示了ncRNAs与铁死亡的相互作用方式，并确定了子痫前期治疗的新分子靶点，从而为临床策略提供理论支持。
