肌肉超声在肌萎缩侧索硬化症患者评估中的应用：一项观察性横断面研究。
Application of muscle ultrasound for the evaluation of patients with amyotrophic lateral sclerosis: An observational cross-sectional study.
机构信息
Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Jalal al Ahmad, Tehran, 1411713135, Iran.
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Muscle Nerve. 2020 Oct;62(4):516-521. doi: 10.1002/mus.27036. Epub 2020 Aug 14.
INTRODUCTION
We evaluated the association between muscle ultrasound, number of motor units, and clinical parameters, and assessed their utility for distinguishing amyotrophic lateral scleorisis (ALS) patients from healthy individuals.
METHODS
Three muscle pairs (abductor pollicis brevis, abductor digiti minimi, and tibialis anterior) of 18 ALS patients and 18 controls underwent muscle ultrasound (echointensity and thickness) and assessment of motor unit number index (MUNIX). The clinical and functional status of participants were also assessed.
RESULTS
Mean age of the patients was 53.8 ± 12.1 years, and score on the ALS Functional Rating Scale-Revised was 38.9 ± 4.1. Echointensity of all tested muscles of ALS participants was significantly higher than that of controls, but there was no significant difference in muscle thickness. Muscle echointensity correlated significantly with clinical and electrophysiological parameters.
CONCLUSION
Echointensity of muscles was highly associated with clinical scales and MUNIX, confirming its relevance as an ancillary diagnostic test in ALS patients.
简介
我们评估了肌肉超声、运动单位数量与临床参数之间的关系，并评估了它们在区分肌萎缩侧索硬化症（ALS）患者与健康个体方面的效用。
方法
18 名 ALS 患者和 18 名对照者的三个肌肉对（拇短展肌、小指展肌和胫骨前肌）接受了肌肉超声（回声强度和厚度）和运动单位数量指数（MUNIX）评估。参与者的临床和功能状态也进行了评估。
结果
患者的平均年龄为 53.8 ± 12.1 岁，修订后的 ALS 功能评定量表评分为 38.9 ± 4.1。所有测试肌肉的 ALS 患者的回声强度均显著高于对照组，但肌肉厚度无显著差异。肌肉回声强度与临床和电生理参数显著相关。
结论
肌肉回声强度与临床量表和 MUNIX 高度相关，证实其作为 ALS 患者辅助诊断测试的相关性。
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