体重指数在宫颈人乳头瘤病毒感染的发病和持续中的作用。

The role of body mass index in incidence and persistence of cervical human papillomavirus infection.

机构信息

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Unit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.

出版信息

Ann Epidemiol. 2020 Sep;49:36-41. doi: 10.1016/j.annepidem.2020.07.011. Epub 2020 Jul 22.

DOI:10.1016/j.annepidem.2020.07.011

PMID:32711054

Abstract

PURPOSE

This study aimed to assess the association between body mass index and incident or persistent cervical high-risk human papillomavirus (hrHPV) infection.

METHODS

This cohort study included 6809 women from the general Danish population who participated in two clinical visits (in 1991-1993 and in 1993-1995). Height and weight were measured by nurses, lifestyle data were obtained by structured interviews, and cervical cytology samples were obtained for hrHPV DNA testing. We conducted log-binomial regression to estimate risk ratios (RRs) with 95% confidence intervals (CIs) of incident and type-specific persistent hrHPV infection according to body mass index, adjusting for age, education, smoking, and the number of sexual partners in the past year.

RESULTS

We found no increased risk of incident hrHPV infection in women who were underweight (RR, 0.97; 95% CI, 0.64-1.48), overweight (RR, 0.98, 95% CI, 0.82-1.17), or obese (RR, 0.93; 95% CI, 0.63-1.36) compared with women of normal weight. The risk of hrHPV persistence was similar in overweight (RR, 0.98; 95% CI, 0.71-1.34) and obese (RR, 1.00; 95% CI, 0.56-1.79) women compared with women of normal weight, whereas underweight women had a lower risk (RR, 0.32; 95% CI, 0.11-0.95).

CONCLUSIONS

Overweight and obesity were not associated with HPV incidence or persistence when adjusting for sexual behavior.

摘要

目的

本研究旨在评估体重指数与宫颈高危型人乳头瘤病毒（hrHPV）感染的发生或持续性之间的关联。

方法

本队列研究纳入了来自丹麦普通人群的 6809 名女性，她们参加了两次临床访视（分别在 1991-1993 年和 1993-1995 年）。护士测量了身高和体重，通过结构化访谈获得了生活方式数据，并采集了宫颈细胞学样本进行 hrHPV DNA 检测。我们进行了对数二项式回归，以估计根据体重指数调整年龄、教育程度、吸烟和过去一年性伴侣数量后，发生和特定类型持续性 hrHPV 感染的风险比（RR）及其 95%置信区间（CI）。

结果

与体重正常的女性相比，体重过轻（RR，0.97；95%CI，0.64-1.48）、超重（RR，0.98，95%CI，0.82-1.17）或肥胖（RR，0.93；95%CI，0.63-1.36）的女性发生 hrHPV 感染的风险并未增加。超重（RR，0.98；95%CI，0.71-1.34）和肥胖（RR，1.00；95%CI，0.56-1.79）女性的 hrHPV 持续性风险与体重正常的女性相似，而体重过轻的女性风险较低（RR，0.32；95%CI，0.11-0.95）。